Demographic trends in the incidence of young-onset colorectal cancer in England: a population-based study, 1974-2015

A. C. Chambers; S. W. Dixon; P. White; A. C. Williams; M. G. Thomas; D. E. Messenger

doi:10.1002/bjs.11486

Demographic trends in the incidence of young-onset colorectal cancer in England: a population-based study, 1974-2015

A. C. Chambers
, S. W. Dixon
, P. White
, A. C. Williams
, M. G. Thomas
, D. E. Messenger

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

Background
Evidence is emerging that colorectal cancer (CRC) incidence is increasing in young adults, but the descriptive epidemiology required to better understand these trends is currently lacking.

Method
A population-based cohort study was carried out of all adults aged 20-49 years diagnosed with CRC in England between 1974 and 2015. Data were extracted from the NCRAS database using ICD9/10 codes for CRC. Temporal trends in age-specific incidence rates (IRs) according to gender, anatomical subsite, index of multiple deprivation (IMD) quintile and geographical region were analysed using Joinpoint regression.

Results
A total of 56 134 new diagnoses of CRC were analysed. The most sustained increase in IR was in the 20-29 age group which is mainly driven by a rise in distal tumours. The magnitude of IR increases was similar in both genders and across Index of Multiple Deprivation quintiles, although the most pronounced increases in incidence were in the southern regions of England.

Conclusion
CRC should no longer be considered a disease of older people: changes in incidence rates should be used to inform future screening policy, preventative strategies and research agendas, as well as increasing public understanding that younger people need to be aware of the symptoms of CRC.

Original language	English
Journal	British Journal of Surgery
Volume	107
Issue number	5
Early online date	9 Mar 2020
DOIs	https://doi.org/10.1002/bjs.11486
Publication status	Published - 18 Mar 2020

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SDG 3 Good Health and Well-being

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Investigating the function of the BCL-3/Beta-canetin complex in promoting intestinal tumorigenesis and acquisition of therapeutic resistance
Williams, A. C. (Principal Investigator)
1/07/18 → 30/09/21
Project: Research

Cite this

@article{b40fd12035ef48b3965db0e69a300a03,

title = "Demographic trends in the incidence of young-onset colorectal cancer in England: a population-based study, 1974-2015",

abstract = "Background Evidence is emerging that colorectal cancer (CRC) incidence is increasing in young adults, but the descriptive epidemiology required to better understand these trends is currently lacking. Method A population-based cohort study was carried out of all adults aged 20-49 years diagnosed with CRC in England between 1974 and 2015. Data were extracted from the NCRAS database using ICD9/10 codes for CRC. Temporal trends in age-specific incidence rates (IRs) according to gender, anatomical subsite, index of multiple deprivation (IMD) quintile and geographical region were analysed using Joinpoint regression. Results A total of 56 134 new diagnoses of CRC were analysed. The most sustained increase in IR was in the 20-29 age group which is mainly driven by a rise in distal tumours. The magnitude of IR increases was similar in both genders and across Index of Multiple Deprivation quintiles, although the most pronounced increases in incidence were in the southern regions of England. Conclusion CRC should no longer be considered a disease of older people: changes in incidence rates should be used to inform future screening policy, preventative strategies and research agendas, as well as increasing public understanding that younger people need to be aware of the symptoms of CRC.",

author = "Chambers, \{A. C.\} and Dixon, \{S. W.\} and P. White and Williams, \{A. C.\} and Thomas, \{M. G.\} and Messenger, \{D. E.\}",

year = "2020",

month = mar,

day = "18",

doi = "10.1002/bjs.11486",

language = "English",

volume = "107",

journal = "British Journal of Surgery",

issn = "0007-1323",

publisher = "Oxford University Press",

number = "5",

}

TY - JOUR

T1 - Demographic trends in the incidence of young-onset colorectal cancer in England

T2 - a population-based study, 1974-2015

AU - Chambers, A. C.

AU - Dixon, S. W.

AU - White, P.

AU - Williams, A. C.

AU - Thomas, M. G.

AU - Messenger, D. E.

PY - 2020/3/18

Y1 - 2020/3/18

N2 - Background Evidence is emerging that colorectal cancer (CRC) incidence is increasing in young adults, but the descriptive epidemiology required to better understand these trends is currently lacking. Method A population-based cohort study was carried out of all adults aged 20-49 years diagnosed with CRC in England between 1974 and 2015. Data were extracted from the NCRAS database using ICD9/10 codes for CRC. Temporal trends in age-specific incidence rates (IRs) according to gender, anatomical subsite, index of multiple deprivation (IMD) quintile and geographical region were analysed using Joinpoint regression. Results A total of 56 134 new diagnoses of CRC were analysed. The most sustained increase in IR was in the 20-29 age group which is mainly driven by a rise in distal tumours. The magnitude of IR increases was similar in both genders and across Index of Multiple Deprivation quintiles, although the most pronounced increases in incidence were in the southern regions of England. Conclusion CRC should no longer be considered a disease of older people: changes in incidence rates should be used to inform future screening policy, preventative strategies and research agendas, as well as increasing public understanding that younger people need to be aware of the symptoms of CRC.

AB - Background Evidence is emerging that colorectal cancer (CRC) incidence is increasing in young adults, but the descriptive epidemiology required to better understand these trends is currently lacking. Method A population-based cohort study was carried out of all adults aged 20-49 years diagnosed with CRC in England between 1974 and 2015. Data were extracted from the NCRAS database using ICD9/10 codes for CRC. Temporal trends in age-specific incidence rates (IRs) according to gender, anatomical subsite, index of multiple deprivation (IMD) quintile and geographical region were analysed using Joinpoint regression. Results A total of 56 134 new diagnoses of CRC were analysed. The most sustained increase in IR was in the 20-29 age group which is mainly driven by a rise in distal tumours. The magnitude of IR increases was similar in both genders and across Index of Multiple Deprivation quintiles, although the most pronounced increases in incidence were in the southern regions of England. Conclusion CRC should no longer be considered a disease of older people: changes in incidence rates should be used to inform future screening policy, preventative strategies and research agendas, as well as increasing public understanding that younger people need to be aware of the symptoms of CRC.

U2 - 10.1002/bjs.11486

DO - 10.1002/bjs.11486

M3 - Article (Academic Journal)

C2 - 32149386

SN - 0007-1323

VL - 107

JO - British Journal of Surgery

JF - British Journal of Surgery

IS - 5

ER -

Demographic trends in the incidence of young-onset colorectal cancer in England: a population-based study, 1974-2015

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Investigating the function of the BCL-3/Beta-canetin complex in promoting intestinal tumorigenesis and acquisition of therapeutic resistance

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