Dendritic Integration of Sensory Evidence in Perceptual Decision-Making

Lukas N Groschner; Laura Chan Wah Hak; Rafal Bogacz; Shamik DasGupta; Gero Miesenböck

doi:10.1016/j.cell.2018.03.075

Dendritic Integration of Sensory Evidence in Perceptual Decision-Making

Lukas N Groschner
, Laura Chan Wah Hak
, Rafal Bogacz
, Shamik DasGupta^*
, Gero Miesenböck^*

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

53 Citations (Scopus)

215 Downloads (Pure)

Abstract

Perceptual decisions require the accumulation of sensory information to a response criterion. Most accounts of how the brain performs this process of temporal integration have focused on evolving patterns of spiking activity. We report that subthreshold changes in membrane voltage can represent accumulating evidence before a choice. αβ core Kenyon cells (αβc KCs) in the mushroom bodies of fruit flies integrate odor-evoked synaptic inputs to action potential threshold at timescales matching the speed of olfactory discrimination. The forkhead box P transcription factor (FoxP) sets neuronal integration and behavioral decision times by controlling the abundance of the voltage-gated potassium channel Shal (KV4) in αβc KC dendrites. αβc KCs thus tailor, through a particular constellation of biophysical properties, the generic process of synaptic integration to the demands of sequential sampling.

Original language	English
Pages (from-to)	894-905.e13
Number of pages	26
Journal	Cell
Volume	173
Issue number	4
Early online date	26 Apr 2018
DOIs	https://doi.org/10.1016/j.cell.2018.03.075
Publication status	Published - 3 May 2018

Keywords

Action Potentials/drug effects
Animals
Barium/pharmacology
Behavior, Animal/drug effects
Brain/metabolism
Cyclohexanols/pharmacology
Dendrites/metabolism
Drosophila/physiology
Drosophila Proteins/genetics
Female
Forkhead Transcription Factors/genetics
Male
Neurons/cytology
Patch-Clamp Techniques
Receptors, Odorant/metabolism
Shal Potassium Channels/genetics
Smell
Synapses/metabolism

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10.1016/j.cell.2018.03.075

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This is the final published version of the article (version of record). It first appeared online via Elsevier at https://www.sciencedirect.com/science/article/pii/S0092867418304471?via%3Dihub. Please refer to any applicable terms of use of the publisher.
Final published version, 17.7 MBLicence: CC BY

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title = "Dendritic Integration of Sensory Evidence in Perceptual Decision-Making",

abstract = "Perceptual decisions require the accumulation of sensory information to a response criterion. Most accounts of how the brain performs this process of temporal integration have focused on evolving patterns of spiking activity. We report that subthreshold changes in membrane voltage can represent accumulating evidence before a choice. αβ core Kenyon cells (αβc KCs) in the mushroom bodies of fruit flies integrate odor-evoked synaptic inputs to action potential threshold at timescales matching the speed of olfactory discrimination. The forkhead box P transcription factor (FoxP) sets neuronal integration and behavioral decision times by controlling the abundance of the voltage-gated potassium channel Shal (KV4) in αβc KC dendrites. αβc KCs thus tailor, through a particular constellation of biophysical properties, the generic process of synaptic integration to the demands of sequential sampling.",

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author = "Groschner, \{Lukas N\} and \{Chan Wah Hak\}, Laura and Rafal Bogacz and Shamik DasGupta and Gero Miesenb{\"o}ck",

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month = may,

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doi = "10.1016/j.cell.2018.03.075",

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T1 - Dendritic Integration of Sensory Evidence in Perceptual Decision-Making

AU - Groschner, Lukas N

AU - Chan Wah Hak, Laura

AU - Bogacz, Rafal

AU - DasGupta, Shamik

AU - Miesenböck, Gero

PY - 2018/5/3

Y1 - 2018/5/3

N2 - Perceptual decisions require the accumulation of sensory information to a response criterion. Most accounts of how the brain performs this process of temporal integration have focused on evolving patterns of spiking activity. We report that subthreshold changes in membrane voltage can represent accumulating evidence before a choice. αβ core Kenyon cells (αβc KCs) in the mushroom bodies of fruit flies integrate odor-evoked synaptic inputs to action potential threshold at timescales matching the speed of olfactory discrimination. The forkhead box P transcription factor (FoxP) sets neuronal integration and behavioral decision times by controlling the abundance of the voltage-gated potassium channel Shal (KV4) in αβc KC dendrites. αβc KCs thus tailor, through a particular constellation of biophysical properties, the generic process of synaptic integration to the demands of sequential sampling.

AB - Perceptual decisions require the accumulation of sensory information to a response criterion. Most accounts of how the brain performs this process of temporal integration have focused on evolving patterns of spiking activity. We report that subthreshold changes in membrane voltage can represent accumulating evidence before a choice. αβ core Kenyon cells (αβc KCs) in the mushroom bodies of fruit flies integrate odor-evoked synaptic inputs to action potential threshold at timescales matching the speed of olfactory discrimination. The forkhead box P transcription factor (FoxP) sets neuronal integration and behavioral decision times by controlling the abundance of the voltage-gated potassium channel Shal (KV4) in αβc KC dendrites. αβc KCs thus tailor, through a particular constellation of biophysical properties, the generic process of synaptic integration to the demands of sequential sampling.

KW - Action Potentials/drug effects

KW - Animals

KW - Barium/pharmacology

KW - Behavior, Animal/drug effects

KW - Brain/metabolism

KW - Cyclohexanols/pharmacology

KW - Dendrites/metabolism

KW - Drosophila/physiology

KW - Drosophila Proteins/genetics

KW - Female

KW - Forkhead Transcription Factors/genetics

KW - Male

KW - Neurons/cytology

KW - Patch-Clamp Techniques

KW - Receptors, Odorant/metabolism

KW - Shal Potassium Channels/genetics

KW - Smell

KW - Synapses/metabolism

UR - http://europepmc.org/articles/PMC5947940

U2 - 10.1016/j.cell.2018.03.075

DO - 10.1016/j.cell.2018.03.075

M3 - Article (Academic Journal)

C2 - 29706545

SN - 0092-8674

VL - 173

SP - 894-905.e13

JO - Cell

JF - Cell

IS - 4

ER -

Dendritic Integration of Sensory Evidence in Perceptual Decision-Making

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Dr Shamik Dasgupta

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Dendritic Integration of Sensory Evidence in Perceptual Decision-Making

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