Dental associations with blood mercury in pregnant women

Jean Golding, Colin Steer, Steve Gregory, Tony Lowery, Joseph R Hibbeln, Caroline Taylor

Research output: Contribution to journalArticle (Academic Journal)peer-review

14 Citations (Scopus)
326 Downloads (Pure)

Abstract

Objectives
There is curiosity concerning the source of mercury that is absorbed into the mother's blood and which may affect the developing fetus. This study therefore sets out to determine the extent to which dental amalgam (DA) may contribute to total blood mercury (TBHg) levels of pregnant women in the UK.

Methods
Whole blood samples and information on diet and socio-demographic factors were collected from pregnant women (n = 4484) enrolled in the Avon Longitudinal Study of Parents and Children (ALSPAC). The whole blood samples were assayed for total mercury levels using inductively coupled plasma dynamic reaction cell mass spectrometry (ICP-DRC-MS), and the women were retrospectively asked about features of their dental care during the pregnancy. Linear regression was used to estimate the relative contributions of DA to TBHg levels (log-transformed) based on R2 values, compared to the results from dietary and socio-demographic variables.

Results
The contribution to the variance of the mothers' TBHg levels by dental variables was 6.47%, a figure comparable to the 8.75% shown for seafood consumption in this population. Dietary and dental variables explained 20.16% of the variance, with socio-demographic variables contributing only a further 3.40%. The number of amalgams in the mouth at the start of pregnancy accounted for most of the variance in dental variables.

Conclusions
Dental amalgam contributes a comparable amount of variance in TBHg to seafood consumption in this population. However, because the measures of DA exposure were imprecise, these findings are likely to be an underestimate. There is no evidence to date in the literature that fetal exposures to mercury from maternal DAs have adverse effects on the developing child, but long-term studies are warranted.
Original languageEnglish
Pages (from-to)216-222
Number of pages7
JournalCommunity Dentistry and Oral Epidemiology
Volume44
Early online date21 Dec 2015
DOIs
Publication statusPublished - Jun 2016

Keywords

  • ALSPAC
  • seafood
  • blood mercury
  • dental amalgam
  • pregnancy

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