Derivation of iPSC lines from two idiopathic ASD patients (OFi001-A, OFi002-A)

Hao Guo; Zhe-long Jin; Xuerui Yao; Jeehun Park; Yong-Pil Gwon; Sungmin Kim; Kee-Pyo Kim; Xiang-Shun Cui; Nam-Hyung Kim; Heejeong Yoo; Dong Wook Han

doi:10.1016/j.scr.2021.102510

Derivation of iPSC lines from two idiopathic ASD patients (OFi001-A, OFi002-A)

Hao Guo, Zhe-long Jin, Xuerui Yao, Jeehun Park, Yong-Pil Gwon, Sungmin Kim, Kee-Pyo Kim, Xiang-Shun Cui, Nam-Hyung Kim, Heejeong Yoo, Dong Wook Han

School of Cellular and Molecular Medicine

Research output: Contribution to journal › Article (Academic Journal) › peer-review

4 Citations (Scopus)

Abstract

Here we described two human induced pluripotent stem cell (hiPSC) lines from peripheral blood mononuclear cells (PBMCs) of idiopathic autism spectrum disorder (ASD) patients through forced expression of OCT4, SOX2, KLF4, and c-MYC. The hiPSC lines displayed morphology, gene expression patterns, and pluripotential differentiation potentials similar to those of human embryonic stem cells (hESCs). The hiPSC lines from idiopathic ASD patients might be useful to unveil the underlying mechanism of idiopathic ASD and finding its therapeutics.

Original language	English
Article number	102510
Number of pages	4
Journal	Stem Cell Research
Volume	56
Early online date	19 Aug 2021
DOIs	https://doi.org/10.1016/j.scr.2021.102510
Publication status	Published - 1 Oct 2021

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title = "Derivation of iPSC lines from two idiopathic ASD patients (OFi001-A, OFi002-A)",

abstract = "Here we described two human induced pluripotent stem cell (hiPSC) lines from peripheral blood mononuclear cells (PBMCs) of idiopathic autism spectrum disorder (ASD) patients through forced expression of OCT4, SOX2, KLF4, and c-MYC. The hiPSC lines displayed morphology, gene expression patterns, and pluripotential differentiation potentials similar to those of human embryonic stem cells (hESCs). The hiPSC lines from idiopathic ASD patients might be useful to unveil the underlying mechanism of idiopathic ASD and finding its therapeutics.",

author = "Hao Guo and Zhe-long Jin and Xuerui Yao and Jeehun Park and Yong-Pil Gwon and Sungmin Kim and Kee-Pyo Kim and Xiang-Shun Cui and Nam-Hyung Kim and Heejeong Yoo and Han, \{Dong Wook\}",

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year = "2021",

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doi = "10.1016/j.scr.2021.102510",

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journal = "Stem Cell Research",

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TY - JOUR

T1 - Derivation of iPSC lines from two idiopathic ASD patients (OFi001-A, OFi002-A)

AU - Guo, Hao

AU - Jin, Zhe-long

AU - Yao, Xuerui

AU - Park, Jeehun

AU - Gwon, Yong-Pil

AU - Kim, Sungmin

AU - Kim, Kee-Pyo

AU - Cui, Xiang-Shun

AU - Kim, Nam-Hyung

AU - Yoo, Heejeong

AU - Han, Dong Wook

PY - 2021/10/1

Y1 - 2021/10/1

N2 - Here we described two human induced pluripotent stem cell (hiPSC) lines from peripheral blood mononuclear cells (PBMCs) of idiopathic autism spectrum disorder (ASD) patients through forced expression of OCT4, SOX2, KLF4, and c-MYC. The hiPSC lines displayed morphology, gene expression patterns, and pluripotential differentiation potentials similar to those of human embryonic stem cells (hESCs). The hiPSC lines from idiopathic ASD patients might be useful to unveil the underlying mechanism of idiopathic ASD and finding its therapeutics.

AB - Here we described two human induced pluripotent stem cell (hiPSC) lines from peripheral blood mononuclear cells (PBMCs) of idiopathic autism spectrum disorder (ASD) patients through forced expression of OCT4, SOX2, KLF4, and c-MYC. The hiPSC lines displayed morphology, gene expression patterns, and pluripotential differentiation potentials similar to those of human embryonic stem cells (hESCs). The hiPSC lines from idiopathic ASD patients might be useful to unveil the underlying mechanism of idiopathic ASD and finding its therapeutics.

UR - https://doi.org/10.1016/j.scr.2021.102510

U2 - 10.1016/j.scr.2021.102510

DO - 10.1016/j.scr.2021.102510

M3 - Article (Academic Journal)

C2 - 34438162

SN - 1873-5061

VL - 56

JO - Stem Cell Research

JF - Stem Cell Research

M1 - 102510

ER -

Derivation of iPSC lines from two idiopathic ASD patients (OFi001-A, OFi002-A)

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