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Descriptive epidemiology of hip and knee replacement in rheumatoid arthritis: an analysis of UK electronic medical records

Research output: Contribution to journalArticle

Original languageEnglish
Number of pages8
JournalSeminars in Arthritis and Rheumatism
Early online date26 Aug 2019
DOIs
DateAccepted/In press - 22 Aug 2019
DateE-pub ahead of print (current) - 26 Aug 2019

Abstract

Objective
To provide descriptive data on rates of total hip replacement (THR) and total knee replacement (TKR) within a large RA cohort and describe variation in risk.

Methods
Incident RA patients (1995 to 2014) were identified from the Clinical Practice Research Datalink (CPRD). First subsequent occurrence of THR and TKR were identified (analysed separately) and incidence rates calculated, stratified by sex, age, BMI, geographic region, and quintiles of the index of multiple deprivation (IMD) score.

Results
There were 27,607 RA patients included, with a total of 1,028 THRs (mean age at surgery: 68.4 years) and 1,366 TKRs (mean age at surgery: 67.6 years), at an overall incidence rate per 1,000 person-years (PYs) [95% CI] of 6.38 [6.00 - 6.78] and 8.57 [8.12 - 9.04], respectively. TKR incidence was similar by gender but THR rates were higher in females than males. Rates of TKR but not THR rose according to BMI. An increasing trend was observed in rates of both outcomes according to age (although not ≥75) but of decreasing rates according to socio-economic deprivation. There was some evidence for regional variation in TKR. The 10-year cumulative incidence was 5.2% [4.9, 5.6] and 7.0% [6.6, 7.4] for THR and TKR, respectively.

Conclusion
We provide generalizable estimates of THR and TKR incidence in the UK RA patient population and note variation across several key variables. Increased BMI was associated with a large increase in TKR but not THR incidence. Increased deprivation was associated with a downward trend in rates of THR and TKR.

    Research areas

  • rheumatoid arthritis, epidemiology, arthroplasty, joint replacement, knee, hip, natural history, incidence, variation, BMI

Documents

Documents

  • Full-text PDF (accepted author manuscript)

    Rights statement: This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Elsevier at https://www.sciencedirect.com/science/article/pii/S004901721930160X. Please refer to any applicable terms of use of the publisher.

    Accepted author manuscript, 390 KB, PDF document

    Embargo ends: 26/08/20

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    Licence: CC BY-NC-ND

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