Design of a multicellular feedback control strategy in a synthetic bacterial consortium

Gianfranco Fiore, Antoni Matyjaszkiewicz, Fabio Annunziata, Claire Grierson, Nigel J. Savery, Lucia Marucci, Mario Di Bernardo*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

3 Citations (Scopus)
269 Downloads (Pure)

Abstract

Living organisms employ endogenous negative feedback loops to maintain homeostasis despite environmental fluctuations. An intriguing challenge in Synthetic Biology is that of designing and implementing synthetic circuits to control host cells’ behavior, thus mimicking what natural evolution has refined and conserved. The high degree of circuit complexity required to accomplish this task, and the intrinsic modularity of classical control schemes, suggest the implementation of synthetic endogenous feedback loops across more than one cell population. The distribution of the sensing, computation and actuation functions required to achieve regulation, to different cell populations within a consortium allows to reduce the genetic engineering in a particular cell and to increase the robustness as well as the possibility of reusing the synthesized circuits. Here we propose and study, in-silico, the design of a synthetic microbial consortium implementing a feedback controller across two cell populations.
Original languageEnglish
Title of host publication2016 IEEE 55th Conference on Decision and Control (CDC 2016)
Subtitle of host publicationProceedings of a meeting held 12-14 December 2016, Las Vegas, Nevada, USA
PublisherInstitute of Electrical and Electronics Engineers (IEEE)
Pages3338-3343
Number of pages6
ISBN (Electronic)9781509018376
ISBN (Print)9781509018383
DOIs
Publication statusPublished - Apr 2017
Event55th IEEE Conference on Decision and Control, CDC 2016 - Las Vegas, United States
Duration: 12 Dec 201614 Dec 2016

Conference

Conference55th IEEE Conference on Decision and Control, CDC 2016
CountryUnited States
CityLas Vegas
Period12/12/1614/12/16

Structured keywords

  • Bristol BioDesign Institute

Keywords

  • synthetic biology

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