Designed for life: biocompatible de novo designed proteins and components

Katie J Grayson, J L Ross Anderson

Research output: Contribution to journalReview article (Academic Journal)peer-review

25 Citations (Scopus)
502 Downloads (Pure)


A principal goal of synthetic biology is the de novo design or redesign of biomolecular components. In addition to revealing fundamentally important information regarding natural biomolecular engineering and biochemistry, functional building blocks will ultimately be provided for applications including the manufacture of valuable products and therapeutics. To fully realize this ambitious goal, the designed components must be biocompatible, working in concert with natural biochemical processes and pathways, while not adversely affecting cellular function. For example, de novo protein design has provided us with a wide repertoire of structures and functions, including those that can be assembled and function in vivo Here we discuss such biocompatible designs, as well as others that have the potential to become biocompatible, including non-protein molecules, and routes to achieving full biological integration.

Original languageEnglish
Article number20180472
Number of pages15
JournalJournal of the Royal Society Interface
Issue number145
Early online date29 Aug 2018
Publication statusPublished - Aug 2018

Structured keywords

  • BrisSynBio
  • Bristol BioDesign Institute


  • de novo protein design
  • synthetic biology
  • biocompatibility


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