Projects per year
Abstract
The construction of artificial membrane proteins from first principles is of fundamental interest and holds considerable promise for new biotechnologies. This review considers the potential advantages of adopting a strictly minimalist approach to the process of membrane protein design. As well as the practical benefits of miniaturisation and simplicity for understanding sequence-structure-function relationships, minimalism should also support the abstract conceptualisation of membrane proteins as modular components for synthetic biology. These ideas are illustrated with selected examples that focus upon α-helical membrane proteins, and which demonstrate how such minimalist membrane proteins might be integrated into living biosystems.
Original language | English |
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Pages (from-to) | 1233–1245 |
Number of pages | 13 |
Journal | Biochemical Society Transactions |
DOIs | |
Publication status | Published - 11 Oct 2019 |
Research Groups and Themes
- BrisSynBio
- Bristol BioDesign Institute
Keywords
- synthetic biology
- Synthetic biology
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Dive into the research topics of 'Designing minimalist membrane proteins'. Together they form a unique fingerprint.Projects
- 1 Finished
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BrisSynBio: Bristol Centre for Synthetic Biology
Woolfson, D. N. (Principal Investigator)
31/07/14 → 31/03/22
Project: Research