Designing minimalist membrane proteins

Paul Curnow

doi:10.1042/BST20190170

Designing minimalist membrane proteins

Paul Curnow^*

^*Corresponding author for this work

Research output: Contribution to journal › Book/Film/Article review (Academic Journal) › peer-review

12 Citations (Scopus)

267 Downloads (Pure)

Abstract

The construction of artificial membrane proteins from first principles is of fundamental interest and holds considerable promise for new biotechnologies. This review considers the potential advantages of adopting a strictly minimalist approach to the process of membrane protein design. As well as the practical benefits of miniaturisation and simplicity for understanding sequence-structure-function relationships, minimalism should also support the abstract conceptualisation of membrane proteins as modular components for synthetic biology. These ideas are illustrated with selected examples that focus upon α-helical membrane proteins, and which demonstrate how such minimalist membrane proteins might be integrated into living biosystems.

Original language	English
Pages (from-to)	1233–1245
Number of pages	13
Journal	Biochemical Society Transactions
DOIs	https://doi.org/10.1042/BST20190170
Publication status	Published - 11 Oct 2019

Research Groups and Themes

BrisSynBio
Bristol BioDesign Institute

Keywords

synthetic biology
Synthetic biology

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10.1042/BST20190170

Full-text PDF (final published version)
This is the final published version of the article (version of record). It first appeared online via Portland Press at https://portlandpress.com/biochemsoctrans/article/47/5/1233/220688/Designing-minimalist-membrane-proteins. Please refer to any applicable terms of use of the publisher.
Final published version, 5.56 MBLicence: CC BY

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BrisSynBio: Bristol Centre for Synthetic Biology
Woolfson, D. N. (Principal Investigator)
31/07/14 → 31/03/22
Project: Research

Cite this

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Designing minimalist membrane proteins

Abstract

Research Groups and Themes

Keywords

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Projects

BrisSynBio: Bristol Centre for Synthetic Biology

Cite this