Designing repeat proteins: A modular approach to protein design

Fabio Parmeggiani, Po-Ssu Huang

Research output: Contribution to journalArticle (Academic Journal)peer-review

31 Citations (Scopus)
584 Downloads (Pure)


Repeat proteins present unique opportunities for engineering because of their modular nature that potentially allows LEGO® like construction of macromolecules. Nature takes advantage of these properties and uses this type of scaffold for recognition, structure, and even signaling purposes. In recent years, new protein modeling tools facilitated the design of novel repeat proteins, creating possibilities beyond naturally occurring scaffolds alone. We highlight here the different design strategies and summarize the various structural families and novel proteins achieved.
Original languageEnglish
Pages (from-to)116-123
Number of pages8
JournalCurrent Opinion in Structural Biology
Early online date3 Mar 2017
Publication statusPublished - Aug 2017

Structured keywords

  • Bristol BioDesign Institute
  • BrisSynBio


  • synthetic biology


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