Designing repeat proteins: A modular approach to protein design

Fabio Parmeggiani; Po-Ssu Huang

doi:10.1016/j.sbi.2017.02.001

Designing repeat proteins: A modular approach to protein design

Fabio Parmeggiani, Po-Ssu Huang

School of Chemistry

Research output: Contribution to journal › Article (Academic Journal) › peer-review

33 Citations (Scopus)

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Abstract

Repeat proteins present unique opportunities for engineering because of their modular nature that potentially allows LEGO® like construction of macromolecules. Nature takes advantage of these properties and uses this type of scaffold for recognition, structure, and even signaling purposes. In recent years, new protein modeling tools facilitated the design of novel repeat proteins, creating possibilities beyond naturally occurring scaffolds alone. We highlight here the different design strategies and summarize the various structural families and novel proteins achieved.

Original language	English
Pages (from-to)	116-123
Number of pages	8
Journal	Current Opinion in Structural Biology
Volume	45
Early online date	3 Mar 2017
DOIs	https://doi.org/10.1016/j.sbi.2017.02.001
Publication status	Published - Aug 2017

Research Groups and Themes

Bristol BioDesign Institute
BrisSynBio

Keywords

synthetic biology

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10.1016/j.sbi.2017.02.001

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This is the author accepted manuscript (AAM). The final published version (version of record) is available online via elsevier at http://www.sciencedirect.com/science/article/pii/S0959440X16301518?via%3Dihub . Please refer to any applicable terms of use of the publisher.
Accepted author manuscript, 17.5 MBLicence: CC BY-NC-ND

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abstract = "Repeat proteins present unique opportunities for engineering because of their modular nature that potentially allows LEGO{\textregistered} like construction of macromolecules. Nature takes advantage of these properties and uses this type of scaffold for recognition, structure, and even signaling purposes. In recent years, new protein modeling tools facilitated the design of novel repeat proteins, creating possibilities beyond naturally occurring scaffolds alone. We highlight here the different design strategies and summarize the various structural families and novel proteins achieved.",

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AU - Parmeggiani, Fabio

AU - Huang, Po-Ssu

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N2 - Repeat proteins present unique opportunities for engineering because of their modular nature that potentially allows LEGO® like construction of macromolecules. Nature takes advantage of these properties and uses this type of scaffold for recognition, structure, and even signaling purposes. In recent years, new protein modeling tools facilitated the design of novel repeat proteins, creating possibilities beyond naturally occurring scaffolds alone. We highlight here the different design strategies and summarize the various structural families and novel proteins achieved.

AB - Repeat proteins present unique opportunities for engineering because of their modular nature that potentially allows LEGO® like construction of macromolecules. Nature takes advantage of these properties and uses this type of scaffold for recognition, structure, and even signaling purposes. In recent years, new protein modeling tools facilitated the design of novel repeat proteins, creating possibilities beyond naturally occurring scaffolds alone. We highlight here the different design strategies and summarize the various structural families and novel proteins achieved.

KW - synthetic biology

U2 - 10.1016/j.sbi.2017.02.001

DO - 10.1016/j.sbi.2017.02.001

M3 - Article (Academic Journal)

C2 - 28267654

SN - 0959-440X

VL - 45

SP - 116

EP - 123

JO - Current Opinion in Structural Biology

JF - Current Opinion in Structural Biology

ER -

Designing repeat proteins: A modular approach to protein design

Abstract

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