Desymmetrisation of biphenyl-based carbohydrate receptors: A nonbonding pillar in one corner of the cage

Lee Challinor, Emmanuel Klein, Anthony P. Davis

Research output: Contribution to journalArticle (Academic Journal)

5 Citations (Scopus)

Abstract

We report a new addition to the family of biphenyl-based carbohydrate receptors, derived by replacing one out of four isophthalamide (diamide) linkages with the corresponding diester. The alteration results in lower binding constants, perhaps reflecting the entropic penalty for lowering receptor symmetry. However, the synthesis allows access to many related host molecules, with potential for restoring and raising affinities and tuning selectivities.

Translated title of the contributionDesymmetrisation of Biphenyl-Based Carbohydrate Receptors: A Nonbonding Pillar in One Corner of the Cage
Original languageEnglish
Pages (from-to)2137-2141
Number of pages5
JournalSYNLETT
Volume2008
Issue number14
DOIs
Publication statusPublished - 22 Aug 2008

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