Detection in the United Kingdom of the Neisseria gonorrhoeae FC428 clone, with ceftriaxone resistance and intermediate resistance to azithromycin, October to December 2018

David W. Eyre*, Katy Town, Teresa Street, Leanne Barker, Nicholas Sanderson, Michelle J. Cole, Hamish Mohammed, Rachel Pitt, Maya Gobin, Charles Irish, Daniel Gardiner, James Sedgwick, Charles Beck, John Saunders, Deborah Turbitt, Clare Cook, Nick Phin, Bavithra Nathan, Paddy Horner, Helen Fifer

*Corresponding author for this work

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Abstract

We describe detection in the United Kingdom (UK) of the drug-resistant Neisseria gonorrhoeae FC428 clone, with ceftriaxone resistance and intermediate azithromycin resistance. Two female patients developed infection following contact with UK-resident men from the same sexual network linked to travel to Ibiza, Spain. One case failed treatment with ceftriaxone, and azithromycin and gentamicin, before successful treatment with ertapenem. Both isolates had indistinguishable whole-genome sequences. Urgent action is essential to contain this drug-resistant strain.

Original languageEnglish
Article number1900147
JournalEurosurveillance
Volume24
Issue number10
DOIs
Publication statusPublished - 7 Mar 2019

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    Eyre, D. W., Town, K., Street, T., Barker, L., Sanderson, N., Cole, M. J., Mohammed, H., Pitt, R., Gobin, M., Irish, C., Gardiner, D., Sedgwick, J., Beck, C., Saunders, J., Turbitt, D., Cook, C., Phin, N., Nathan, B., Horner, P., & Fifer, H. (2019). Detection in the United Kingdom of the Neisseria gonorrhoeae FC428 clone, with ceftriaxone resistance and intermediate resistance to azithromycin, October to December 2018. Eurosurveillance, 24(10), [1900147]. https://doi.org/10.2807/1560-7917.ES.2019.24.10.1900147