Detection of tetanus toxoid-specific memory T cells in equine lymph nodes but not in peripheral blood.

Jan Frayne, Christopher R Stokes

Research output: Contribution to journalArticle (Academic Journal)peer-review

5 Citations (Scopus)

Abstract

The use of tetanus toxoid as a recall antigen to investigate equine immune responses would be, in theory, a useful and cost-effective model in vitro. However, by using various regimens for culturing peripheral blood mononuclear cells from horses previously immunised with toxoid no proliferative response to the antigen was obtained in vitro, whereas lymph node mononuclear cells from the same animals proliferated significantly in response to it. The lack of response by the peripheral blood mononuclear cells was not due to the presence of a suppressive factor but to a lack of recognition of the antigen by the T cells of the peripheral blood.
Original languageEnglish
Pages (from-to)79-81
JournalResearch in Veterinary Science
Volume59
Issue number1
Publication statusPublished - 1995

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