TY - JOUR
T1 - Detection of tetanus toxoid-specific memory T cells in equine lymph nodes but not in peripheral blood.
AU - Frayne, Jan
AU - Stokes, Christopher R
PY - 1995
Y1 - 1995
N2 - The use of tetanus toxoid as a recall antigen to investigate equine immune responses would be, in theory, a useful and cost-effective model in vitro. However, by using various regimens for culturing peripheral blood mononuclear cells from horses previously immunised with toxoid no proliferative response to the antigen was obtained in vitro, whereas lymph node mononuclear cells from the same animals proliferated significantly in response to it. The lack of response by the peripheral blood mononuclear cells was not due to the presence of a suppressive factor but to a lack of recognition of the antigen by the T cells of the peripheral blood.
AB - The use of tetanus toxoid as a recall antigen to investigate equine immune responses would be, in theory, a useful and cost-effective model in vitro. However, by using various regimens for culturing peripheral blood mononuclear cells from horses previously immunised with toxoid no proliferative response to the antigen was obtained in vitro, whereas lymph node mononuclear cells from the same animals proliferated significantly in response to it. The lack of response by the peripheral blood mononuclear cells was not due to the presence of a suppressive factor but to a lack of recognition of the antigen by the T cells of the peripheral blood.
M3 - Article (Academic Journal)
SN - 0034-5288
VL - 59
SP - 79
EP - 81
JO - Research in Veterinary Science
JF - Research in Veterinary Science
IS - 1
ER -