TY - JOUR
T1 - Determinants of outcome after head cooling for neonatal encephalopathy
AU - Wyatt, S
AU - Gluckman, PD
AU - Liu, PY
AU - Azzopardi, D
AU - Ballard, R
AU - Edwards, AD
AU - Ferriero, DM
AU - Polin, RA
AU - Roberston, CM
AU - Thoresen, M
AU - Whitelaw, A
AU - Gunn, AJ
AU - the Coolcap Study, Group
N1 - Publisher: American Academy of Pediatrics
PY - 2007/5
Y1 - 2007/5
N2 - OBJECTIVE. The goal of this study was to evaluate the role of factors that may determine the efficacy of treatment with delayed head cooling and mild systemic hypothermia for neonatal encephalopathy.
METHODS. A total of 218 term infants with moderate to severe neonatal encephalopathy plus abnormal amplitude-integrated electroencephalographic recordings, assigned randomly to head cooling for 72 hours, starting within 6 hours after birth (with the rectal temperature maintained at 34.5 ± 0.5°C), or conventional care, were studied. Death or severe disability at 18 months of age was assessed in a multicenter, randomized, controlled study (the CoolCap trial).
RESULTS. Treatment, lower encephalopathy grade, lower birth weight, greater amplitude-integrated electroencephalographic amplitude, absence of seizures, and higher Apgar score, but not gender or gestational age, were associated significantly with better outcomes. In a multivariate analysis, each of the individually predictive factors except for Apgar score remained predictive. There was a significant interaction between treatment and birth weight, categorized as ≥25th or
AB - OBJECTIVE. The goal of this study was to evaluate the role of factors that may determine the efficacy of treatment with delayed head cooling and mild systemic hypothermia for neonatal encephalopathy.
METHODS. A total of 218 term infants with moderate to severe neonatal encephalopathy plus abnormal amplitude-integrated electroencephalographic recordings, assigned randomly to head cooling for 72 hours, starting within 6 hours after birth (with the rectal temperature maintained at 34.5 ± 0.5°C), or conventional care, were studied. Death or severe disability at 18 months of age was assessed in a multicenter, randomized, controlled study (the CoolCap trial).
RESULTS. Treatment, lower encephalopathy grade, lower birth weight, greater amplitude-integrated electroencephalographic amplitude, absence of seizures, and higher Apgar score, but not gender or gestational age, were associated significantly with better outcomes. In a multivariate analysis, each of the individually predictive factors except for Apgar score remained predictive. There was a significant interaction between treatment and birth weight, categorized as ≥25th or
U2 - 10.1542/peds.2006-2839
DO - 10.1542/peds.2006-2839
M3 - Article (Academic Journal)
C2 - 17473091
SN - 1098-4275
VL - 119 (5)
SP - 912
EP - 921
JO - Pediatrics
JF - Pediatrics
ER -