Determining Nanorod Dimensions in Dispersion with Size Anisotropy Nanoparticle Tracking Analysis

William H Hoffmann; Bo Gao; Niall Mulkerns; Alexander G Hinton; Simon Hanna; Simon R Hall; Henkjan Gersen

doi:10.1039/D2CP00432A

Determining Nanorod Dimensions in Dispersion with Size Anisotropy Nanoparticle Tracking Analysis

William H Hoffmann, Bo Gao, Niall Mulkerns, Alexander G Hinton, Simon Hanna, Simon R Hall, Henkjan Gersen^*

^*Corresponding author for this work

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Abstract

Control over nanorod dimensions is critical to their application, requiring fast, robust characterisation of their volume and aspect ratio whilst in their working medium. Here, we present an extension of Nanoparticle Tracking Analysis which determines the aspect ratio of nanoparticles from the polarisation state of scattered light in addition to a hydrodynamic diameter from Brownian motion. These data, in principle, permit the determination of nanorod dimensions of any composition using Nanoparticle Tracking Analysis. The results are compared with transmission electron microscopy and show that this technique can additionally determine the aggregation state of the nanorod dispersion if single nanorod dimensions are determined with a complementary technique. We also show it is possible to differentiate nanoparticles of similar hydrodynamic diameter by their depolarised scattering. Finally, we assess the ability of the technique to output nanorod dimensions and suggest ways to further improve the approach. This technique will enable rapid characterisation of nanorods in suspension, which are important tools for nanotechnology.

Original language	English
Pages (from-to)	13040-13048
Number of pages	9
Journal	Physical Chemistry Chemical Physics
Volume	24
Issue number	21
DOIs	https://doi.org/10.1039/D2CP00432A
Publication status	Published - 18 May 2022

Bibliographical note

Funding Information:
W. H. H. thanks Adrian Crimp and his team at the University of Bristol Mechanical Workshop for machining components of the device as well as Michael O'Donnell for discussions about light scattering theory. W. H. H., S. R. H., and H. G. acknowledge the Engineering and Physical Sciences Research Council (EPSRC) for funding under grant number EP/L016648/1. W. H. H. and S. R. H. acknowledge support by MagnaPharm, a European Union Horizon 2020 Research and Innovation programme under grant agreement number 736899. B. G. acknowledges the China Scholarship Council and the University of Bristol for funding and providing the High Performance Computing platform. N. M. and H. G. acknowledge support from an NPIF grant cofunded by Carbometrics under grant number EP/R51245/X. Electron microscopy studies were carried out in the Chemical Imaging Facility, University of Bristol with equipment funded by EPSRC under Grant “Atoms to Applications” EP/K035746/1.

Publisher Copyright:
© 2022 The Royal Society of Chemistry.

Keywords

NANORODS
Light scattering
nanoparticle tracking analysis
Brownian motion
Depolarization
Hydrodynamic diameter
Particle characterization

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2 Citations
4 Article (Academic Journal)

Measuring the Refractive Index and Sub-Nanometre Surface Functionalisation of Nanoparticles in Suspension
Mulkerns, N., Hoffmann, W. H., Ramos Soriano, F. J., de la Cruz, N., Garcia Millan, T., Harniman, R. L., Lindsay, I. D., Seddon, A. M., Galan, M. C. & Gersen, H., 9 Jun 2022, In: Nanoscale. 14, 22, p. 8145-8152 8 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-review

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6 Citations (Scopus)

114 Downloads (Pure)
Laser-induced convection shifts size distributions in Nanoparticle Tracking Analysis
Hoffmann, W. H., Mulkerns, N., Hall, S. R. & Gersen, H., 7 Oct 2021, In: Nanoscale Advances. 3, 19, p. 5694 - 5702 9 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Direct evidence of lack of colocalisation of fluorescently labelled gold labels used in correlative light electron microscopy
Miles, B. T., Greenwood, A. B., Benito-Alifonso, D., Tanner, H., Galan, M. C., Verkade, P. & Gersen, H., 20 Mar 2017, In: Scientific Reports. 7, 7 p., 44666.
Research output: Contribution to journal › Article (Academic Journal) › peer-review

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13 Citations (Scopus)

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Cite this

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title = "Determining Nanorod Dimensions in Dispersion with Size Anisotropy Nanoparticle Tracking Analysis",

abstract = "Control over nanorod dimensions is critical to their application, requiring fast, robust characterisation of their volume and aspect ratio whilst in their working medium. Here, we present an extension of Nanoparticle Tracking Analysis which determines the aspect ratio of nanoparticles from the polarisation state of scattered light in addition to a hydrodynamic diameter from Brownian motion. These data, in principle, permit the determination of nanorod dimensions of any composition using Nanoparticle Tracking Analysis. The results are compared with transmission electron microscopy and show that this technique can additionally determine the aggregation state of the nanorod dispersion if single nanorod dimensions are determined with a complementary technique. We also show it is possible to differentiate nanoparticles of similar hydrodynamic diameter by their depolarised scattering. Finally, we assess the ability of the technique to output nanorod dimensions and suggest ways to further improve the approach. This technique will enable rapid characterisation of nanorods in suspension, which are important tools for nanotechnology.",

keywords = "NANORODS, Light scattering, nanoparticle tracking analysis, Brownian motion, Depolarization, Hydrodynamic diameter, Particle characterization",

author = "Hoffmann, {William H} and Bo Gao and Niall Mulkerns and Hinton, {Alexander G} and Simon Hanna and Hall, {Simon R} and Henkjan Gersen",

note = "Funding Information: W. H. H. thanks Adrian Crimp and his team at the University of Bristol Mechanical Workshop for machining components of the device as well as Michael O'Donnell for discussions about light scattering theory. W. H. H., S. R. H., and H. G. acknowledge the Engineering and Physical Sciences Research Council (EPSRC) for funding under grant number EP/L016648/1. W. H. H. and S. R. H. acknowledge support by MagnaPharm, a European Union Horizon 2020 Research and Innovation programme under grant agreement number 736899. B. G. acknowledges the China Scholarship Council and the University of Bristol for funding and providing the High Performance Computing platform. N. M. and H. G. acknowledge support from an NPIF grant cofunded by Carbometrics under grant number EP/R51245/X. Electron microscopy studies were carried out in the Chemical Imaging Facility, University of Bristol with equipment funded by EPSRC under Grant “Atoms to Applications” EP/K035746/1. Publisher Copyright: {\textcopyright} 2022 The Royal Society of Chemistry.",

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AU - Hanna, Simon

AU - Hall, Simon R

AU - Gersen, Henkjan

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N2 - Control over nanorod dimensions is critical to their application, requiring fast, robust characterisation of their volume and aspect ratio whilst in their working medium. Here, we present an extension of Nanoparticle Tracking Analysis which determines the aspect ratio of nanoparticles from the polarisation state of scattered light in addition to a hydrodynamic diameter from Brownian motion. These data, in principle, permit the determination of nanorod dimensions of any composition using Nanoparticle Tracking Analysis. The results are compared with transmission electron microscopy and show that this technique can additionally determine the aggregation state of the nanorod dispersion if single nanorod dimensions are determined with a complementary technique. We also show it is possible to differentiate nanoparticles of similar hydrodynamic diameter by their depolarised scattering. Finally, we assess the ability of the technique to output nanorod dimensions and suggest ways to further improve the approach. This technique will enable rapid characterisation of nanorods in suspension, which are important tools for nanotechnology.

AB - Control over nanorod dimensions is critical to their application, requiring fast, robust characterisation of their volume and aspect ratio whilst in their working medium. Here, we present an extension of Nanoparticle Tracking Analysis which determines the aspect ratio of nanoparticles from the polarisation state of scattered light in addition to a hydrodynamic diameter from Brownian motion. These data, in principle, permit the determination of nanorod dimensions of any composition using Nanoparticle Tracking Analysis. The results are compared with transmission electron microscopy and show that this technique can additionally determine the aggregation state of the nanorod dispersion if single nanorod dimensions are determined with a complementary technique. We also show it is possible to differentiate nanoparticles of similar hydrodynamic diameter by their depolarised scattering. Finally, we assess the ability of the technique to output nanorod dimensions and suggest ways to further improve the approach. This technique will enable rapid characterisation of nanorods in suspension, which are important tools for nanotechnology.

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ER -

Determining Nanorod Dimensions in Dispersion with Size Anisotropy Nanoparticle Tracking Analysis

Abstract

Bibliographical note

Keywords

Access to Document

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Research output

Measuring the Refractive Index and Sub-Nanometre Surface Functionalisation of Nanoparticles in Suspension

Laser-induced convection shifts size distributions in Nanoparticle Tracking Analysis

Direct evidence of lack of colocalisation of fluorescently labelled gold labels used in correlative light electron microscopy

Cite this