Determining Stroke Onset Time Using Quantitative MRI: High Accuracy, Sensitivity and Specificity Obtained from Magnetic Resonance Relaxation Times

Bryony McGarry, Harriet Rogers, Michael Knight, Kimmo Jokivarsi, Olli Grohn, Risto Kauppinen

Research output: Contribution to journalArticle (Academic Journal)peer-review

1 Citation (Scopus)
299 Downloads (Pure)

Abstract

Many ischaemic stroke patients are ineligible for thrombolytic therapy due to unknown onset time. Quantitative MRI (qMRI) is a potential surrogate for stroke timing. Rats were subjected to permanent middle cerebral artery occlusion and qMRI parameters including hemispheric differences in apparent diffusion coefficient, T2-weighted signal intensities, T1 and T2 relax- ation times (qT1, qT2) and f1, f2 and Voverlap were measured at hourly intervals at 4.7 or 9.4 T. Accuracy and sensitivity for identifying strokes scanned within and beyond 3 h of onset was determined. Accuracy for Voverlap, f2 and qT2 (>90%) was significantly higher than other param- eters. At a specificity of 1, sensitivity was highest for Voverlap (0.90) and f2 (0.80), indicating promise of these qMRI indices in the clinical assessment of stroke onset time.
Original languageEnglish
Pages (from-to)60
Number of pages65
JournalCerebrovascular Diseases
Volume6
DOIs
Publication statusPublished - 26 Aug 2016

Structured keywords

  • Brain and Behaviour
  • Cognitive Science

Keywords

  • Quantitative MRI
  • Ischaemia
  • Wake-up stroke

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