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Determining the Relationship Between Hot Flushes and LH Pulses in Menopausal Women Using Mathematical Modeling

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Determining the Relationship Between Hot Flushes and LH Pulses in Menopausal Women Using Mathematical Modeling. / Prague, Julia K.; Voliotis, Margaritis; Clarke, Sophie; Comninos, Alexander N.; Abbara, Ali; Jayasena, Channa N.; Roberts, Rachel E.; Yang, Lisa; Veldhuis, Johannes D.; Tsaneva-Atanasova, Krasimira; McArdle, Craig A.; Dhillo, Waljit S.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 104, No. 9, 01.09.2019, p. 3628-3636.

Research output: Contribution to journalArticle

Harvard

Prague, JK, Voliotis, M, Clarke, S, Comninos, AN, Abbara, A, Jayasena, CN, Roberts, RE, Yang, L, Veldhuis, JD, Tsaneva-Atanasova, K, McArdle, CA & Dhillo, WS 2019, 'Determining the Relationship Between Hot Flushes and LH Pulses in Menopausal Women Using Mathematical Modeling', Journal of Clinical Endocrinology and Metabolism, vol. 104, no. 9, pp. 3628-3636. https://doi.org/10.1210/jc.2018-02797

APA

Prague, J. K., Voliotis, M., Clarke, S., Comninos, A. N., Abbara, A., Jayasena, C. N., ... Dhillo, W. S. (2019). Determining the Relationship Between Hot Flushes and LH Pulses in Menopausal Women Using Mathematical Modeling. Journal of Clinical Endocrinology and Metabolism, 104(9), 3628-3636. https://doi.org/10.1210/jc.2018-02797

Vancouver

Prague JK, Voliotis M, Clarke S, Comninos AN, Abbara A, Jayasena CN et al. Determining the Relationship Between Hot Flushes and LH Pulses in Menopausal Women Using Mathematical Modeling. Journal of Clinical Endocrinology and Metabolism. 2019 Sep 1;104(9):3628-3636. https://doi.org/10.1210/jc.2018-02797

Author

Prague, Julia K. ; Voliotis, Margaritis ; Clarke, Sophie ; Comninos, Alexander N. ; Abbara, Ali ; Jayasena, Channa N. ; Roberts, Rachel E. ; Yang, Lisa ; Veldhuis, Johannes D. ; Tsaneva-Atanasova, Krasimira ; McArdle, Craig A. ; Dhillo, Waljit S. / Determining the Relationship Between Hot Flushes and LH Pulses in Menopausal Women Using Mathematical Modeling. In: Journal of Clinical Endocrinology and Metabolism. 2019 ; Vol. 104, No. 9. pp. 3628-3636.

Bibtex

@article{b05969f8b6e845cbbc3b5c1e509b19f9,
title = "Determining the Relationship Between Hot Flushes and LH Pulses in Menopausal Women Using Mathematical Modeling",
abstract = "BACKGROUND: Hypothalamic kisspeptin/neurokinin B/dynorphin (KNDy) neurones regulate LH pulsatility. It is widely accepted that the menopausal hot flush (HF) consistently synchronises with the LH pulse. This suggests that the hypothalamic KNDy neurones are implicated in generating LH pulsatility and HF. Using a modern immunoassay and mathematical modelling we investigated if the HF and LH pulse was consistently synchronised in menopausal women.METHODS: Eleven menopausal women (51-62yrs experiencing ≥7 HF/24hrs) attended for an 8 hour study where they self-reported HF and underwent peripheral blood sampling every 10 mins. LH pulsatility was determined using two mathematical models: blinded deconvolution analysis and Bayesian spectrum analysis. The probability that the LH pulse and HF event intervals matched was estimated using the interval distributions observed in our data.RESULTS: Ninety-six HF were self-reported, and 82 LH pulses were identified by blinded deconvolution analysis. Using both models, the probability that the two event intervals matched was low in the majority of participants (mean P=0.24 (P=1 reflects perfect association)).INTERPRETATION: Our data challenges the widely accepted dogma that HF consistently synchronise with an LH pulse, and so has clinically important therapeutic and mechanistic implications.",
author = "Prague, {Julia K.} and Margaritis Voliotis and Sophie Clarke and Comninos, {Alexander N.} and Ali Abbara and Jayasena, {Channa N.} and Roberts, {Rachel E.} and Lisa Yang and Veldhuis, {Johannes D.} and Krasimira Tsaneva-Atanasova and McArdle, {Craig A.} and Dhillo, {Waljit S.}",
note = "Copyright {\circledC} 2019 Endocrine Society.",
year = "2019",
month = "9",
day = "1",
doi = "10.1210/jc.2018-02797",
language = "English",
volume = "104",
pages = "3628--3636",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "Oxford University Press",
number = "9",

}

RIS - suitable for import to EndNote

TY - JOUR

T1 - Determining the Relationship Between Hot Flushes and LH Pulses in Menopausal Women Using Mathematical Modeling

AU - Prague, Julia K.

AU - Voliotis, Margaritis

AU - Clarke, Sophie

AU - Comninos, Alexander N.

AU - Abbara, Ali

AU - Jayasena, Channa N.

AU - Roberts, Rachel E.

AU - Yang, Lisa

AU - Veldhuis, Johannes D.

AU - Tsaneva-Atanasova, Krasimira

AU - McArdle, Craig A.

AU - Dhillo, Waljit S.

N1 - Copyright © 2019 Endocrine Society.

PY - 2019/9/1

Y1 - 2019/9/1

N2 - BACKGROUND: Hypothalamic kisspeptin/neurokinin B/dynorphin (KNDy) neurones regulate LH pulsatility. It is widely accepted that the menopausal hot flush (HF) consistently synchronises with the LH pulse. This suggests that the hypothalamic KNDy neurones are implicated in generating LH pulsatility and HF. Using a modern immunoassay and mathematical modelling we investigated if the HF and LH pulse was consistently synchronised in menopausal women.METHODS: Eleven menopausal women (51-62yrs experiencing ≥7 HF/24hrs) attended for an 8 hour study where they self-reported HF and underwent peripheral blood sampling every 10 mins. LH pulsatility was determined using two mathematical models: blinded deconvolution analysis and Bayesian spectrum analysis. The probability that the LH pulse and HF event intervals matched was estimated using the interval distributions observed in our data.RESULTS: Ninety-six HF were self-reported, and 82 LH pulses were identified by blinded deconvolution analysis. Using both models, the probability that the two event intervals matched was low in the majority of participants (mean P=0.24 (P=1 reflects perfect association)).INTERPRETATION: Our data challenges the widely accepted dogma that HF consistently synchronise with an LH pulse, and so has clinically important therapeutic and mechanistic implications.

AB - BACKGROUND: Hypothalamic kisspeptin/neurokinin B/dynorphin (KNDy) neurones regulate LH pulsatility. It is widely accepted that the menopausal hot flush (HF) consistently synchronises with the LH pulse. This suggests that the hypothalamic KNDy neurones are implicated in generating LH pulsatility and HF. Using a modern immunoassay and mathematical modelling we investigated if the HF and LH pulse was consistently synchronised in menopausal women.METHODS: Eleven menopausal women (51-62yrs experiencing ≥7 HF/24hrs) attended for an 8 hour study where they self-reported HF and underwent peripheral blood sampling every 10 mins. LH pulsatility was determined using two mathematical models: blinded deconvolution analysis and Bayesian spectrum analysis. The probability that the LH pulse and HF event intervals matched was estimated using the interval distributions observed in our data.RESULTS: Ninety-six HF were self-reported, and 82 LH pulses were identified by blinded deconvolution analysis. Using both models, the probability that the two event intervals matched was low in the majority of participants (mean P=0.24 (P=1 reflects perfect association)).INTERPRETATION: Our data challenges the widely accepted dogma that HF consistently synchronise with an LH pulse, and so has clinically important therapeutic and mechanistic implications.

UR - http://www.scopus.com/inward/record.url?scp=85070055256&partnerID=8YFLogxK

U2 - 10.1210/jc.2018-02797

DO - 10.1210/jc.2018-02797

M3 - Article

VL - 104

SP - 3628

EP - 3636

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 9

ER -