Development and validation of consensus contouring guidelines for adjuvant radiation therapy for bladder cancer after radical cystectomy

Brian C. Baumann, Walter R. Bosch, Amit Bahl, Alison J. Birtle, Rodney H. Breau, Amarnath Challapalli, Albert J. Chang, Ananya Choudhury, Sia Daneshmand, Ali El-Gayed, Adam Feldman, Steven E. Finkelstein, Thomas J. Guzzo, Serena Hilman, Ashesh Jani, S. Bruce Malkowicz, Constantine A. Mantz, Viraj Master, Anita Mitra, Vedang MurthySima P. Porten, Pierre M. Richaud, Paul Sargos, Jason A. Efstathiou, Libni J. Eapen, John P. Christodouleas

Research output: Contribution to journalArticle (Academic Journal)peer-review

25 Citations (Scopus)

Abstract

Purpose

To develop multi-institutional consensus clinical target volumes (CTVs) and organs at risk (OARs) for male and female bladder cancer patients undergoing adjuvant radiation therapy (RT) in clinical trials.

Methods and Materials

We convened a multidisciplinary group of bladder cancer specialists from 15 centers and 5 countries. Six radiation oncologists and 7 urologists participated in the development of the initial contours. The group proposed initial language for the CTVs and OARs, and each radiation oncologist contoured them on computed tomography scans of a male and female cystectomy patient with input from ≥1 urologist. On the basis of the initial contouring, the group updated its CTV and OAR descriptions. The cystectomy bed, the area of greatest controversy, was contoured by another 6 radiation oncologists, and the cystectomy bed contouring language was again updated. To determine whether the revised language produced consistent contours, CTVs and OARs were redrawn by 6 additional radiation oncologists. We evaluated their contours for level of agreement using the Landis-Koch interpretation of the κ statistic.

Results

The group proposed that patients at elevated risk for local-regional failure with negative margins should be treated to the pelvic nodes alone (internal/external iliac, distal common iliac, obturator, and presacral), whereas patients with positive margins should be treated to the pelvic nodes and cystectomy bed. Proposed OARs included the rectum, bowel space, bone marrow, and urinary diversion. Consensus language describing the CTVs and OARs was developed and externally validated. The revised instructions were found to produce consistent contours.

Conclusions

Consensus descriptions of CTVs and OARs were successfully developed and can be used in clinical trials of adjuvant radiation therapy for bladder cancer.

Original languageEnglish
Pages (from-to)78-86
Number of pages9
JournalInternational Journal of Radiation Oncology - Biology - Physics
Volume91
Issue number1
Early online date7 May 2016
DOIs
Publication statusPublished - 1 Sep 2016

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