Development and validation of the Multimorbidity Treatment Burden Questionnaire (MTBQ)

Research output: Contribution to journalArticle (Academic Journal)

18 Citations (Scopus)
224 Downloads (Pure)

Abstract

Objective: To develop and validate a new scale to assess treatment burden (the effort of looking after one's health) for patients with multimorbidity. Methods: Design: mixed-methods Setting: UK primary care Participants: Content of the Multimorbidity Treatment Burden Questionnaire (MTBQ) was based on a literature review and views from a patient and public involvement group. Face validity was assessed through cognitive interviews. The scale was piloted and the final version was tested in 1546 adults with multimorbidity (mean age 71 years) who took part in the 3D Study, a cluster randomised controlled trial. For each question, we examined the proportion of missing data and the distribution of responses. Factor analysis, Cronbach's alpha, Spearman's rank correlations and longitudinal regression assessed dimensional structure, internal consistency reliability, construct validity and responsiveness respectively. We assessed interpretability by grouping the global MTBQ scores into zero and tertiles (>0) and comparing participant characteristics across these categories. Results: Cognitive interviews found good acceptability and content validity. Factor analysis supported a one-factor solution. Cronbach's alpha was 0.83, indicating internal consistency reliability. The MTBQ score had a positive association with a comparator treatment burden scale (Rs 0.58, p<0.0001) and with self-reported disease burden (Rs 0.43, p<0.0001) and a negative association with quality of life (Rs -0.36, p<0.0001) and self-rated health (Rs -0.36, p<0.0001). Female participants, younger participants and participants with mental health conditions were more likely to have high treatment burden scores. Changes in MTBQ score over nine-month follow-up were associated, as expected, with changes in measures of quality of life (EQ-5D-5L) and patient-centred care (PACIC). Conclusion: The MTBQ is a ten-item measure of treatment burden for patients with multimorbidity that has demonstrated good content validity, construct validity, reliability and responsiveness. It is a useful research tool for assessing the impact of interventions on treatment burden.
Original languageEnglish
Article numbere019413
Number of pages10
JournalBMJ Open
Volume8
DOIs
Publication statusPublished - 12 Apr 2018

Structured keywords

  • BTC (Bristol Trials Centre)
  • BRTC

Keywords

  • Treatment burden
  • primary care
  • Questionnaire development
  • multimorbidity
  • Patient Reported Outcome Measures
  • QUESTIONNAIRE

Fingerprint Dive into the research topics of 'Development and validation of the Multimorbidity Treatment Burden Questionnaire (MTBQ)'. Together they form a unique fingerprint.

  • Cite this