Development of a core outcome set to determine the overall treatment success of acute uncomplicated appendicitis in children: a study protocol

Fran Sherratt, Lucy Beasant, Jane Blazeby, Bridget Young, Esther Crawley

Research output: Contribution to journalArticle (Academic Journal)peer-review

9 Citations (Scopus)
265 Downloads (Pure)

Abstract

Introduction In recent years, there has been growing interest in alternatives to appendicectomy. In particular, non-operative treatment of appendicitis, with antibiotics alone, has been proposed as a potential treatment. A small number of randomised controlled trials (RCTs) in adults and, more recently, children suggest that antibiotic treatment may be a valid alternative to appendicectomy. However, there is currently insufficient data to justify its widespread use. Prior to performing further efficacy studies of the treatment of appendicitis in children, it is imperative to identify the most relevant outcome measures for inclusion in the design of comparative studies. This is of particular importance when evaluating a novel treatment approach since the outcomes of importance may differ from those commonly reported with traditional therapies. A review of the relevant literature and electronic resources failed to identify a core outcome set (COS) for children with appendicitis. We aim to define a COS for the measurement of treatment interventions in children (<18 years) with acute appendicitis. Methods and analysis This project will entail: (1) a systematic review to identify previously reported acute uncomplicated appendicitis treatment outcomes; (2) assembly of stakeholder panels (paediatric and adult surgeons, patients and parents); (3) a three-stage Delphi process; and (4) a final consensus meeting to complete the COS.
Original languageEnglish
Article numbere000151
Number of pages6
JournalBMJ Paediatrics Open
Volume1
Issue number1
Early online date11 Aug 2017
DOIs
Publication statusPublished - 2017

Structured keywords

  • Centre for Surgical Research

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