Developmental profiles of SUMOylation pathway proteins in rat cerebrum and cerebellum

Fernando Josa Prado, Jia Luo, Philip Rubin, Jeremy Henley, Kevin Wilkinson

Research output: Contribution to journalArticle (Academic Journal)peer-review

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Protein SUMOylation regulates multiple processes involved in the differentiation and maturation of cells and tissues during development. Despite this, relatively little is known about the spatial and temporal regulation of proteins that mediate SUMOylation and deSUMOylation in the CNS. Here we monitor the expression of key SUMO pathway proteins and levels of substrate protein SUMOylation in the forebrain and cerebellum of Wistar rats during development. Overall, the SUMOylation machinery is more highly-expressed at E18 and decreases thereafter, as previously described. All of the proteins investigated are less abundant in adult than in embryonic brain. Furthermore, we show for first time that the profiles differ between cerebellum and cerebrum, indicating differential regional regulation of some of the proteins analysed. These data provide further basic observation that may open a new perspective of research about the role of SUMOylation in the development of different brain regions.
Original languageEnglish
Article numbere0212857
Number of pages16
JournalPLoS ONE
Issue number2
Publication statusPublished - 22 Feb 2019


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