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Developmental profiles of SUMOylation pathway proteins in rat cerebrum and cerebellum

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Developmental profiles of SUMOylation pathway proteins in rat cerebrum and cerebellum. / Josa Prado, Fernando; Luo, Jia; Rubin, Philip; Henley, Jeremy; Wilkinson, Kevin.

In: PLoS ONE, Vol. 14, No. 2, e0212857, 22.02.2019.

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Josa Prado, Fernando ; Luo, Jia ; Rubin, Philip ; Henley, Jeremy ; Wilkinson, Kevin. / Developmental profiles of SUMOylation pathway proteins in rat cerebrum and cerebellum. In: PLoS ONE. 2019 ; Vol. 14, No. 2.

Bibtex

@article{0b1e930ffcbd45f08943a9bf47677268,
title = "Developmental profiles of SUMOylation pathway proteins in rat cerebrum and cerebellum",
abstract = "Protein SUMOylation regulates multiple processes involved in the differentiation and maturation of cells and tissues during development. Despite this, relatively little is known about the spatial and temporal regulation of proteins that mediate SUMOylation and deSUMOylation in the CNS. Here we monitor the expression of key SUMO pathway proteins and levels of substrate protein SUMOylation in the forebrain and cerebellum of Wistar rats during development. Overall, the SUMOylation machinery is more highly-expressed at E18 and decreases thereafter, as previously described. All of the proteins investigated are less abundant in adult than in embryonic brain. Furthermore, we show for first time that the profiles differ between cerebellum and cerebrum, indicating differential regional regulation of some of the proteins analysed. These data provide further basic observation that may open a new perspective of research about the role of SUMOylation in the development of different brain regions.",
author = "{Josa Prado}, Fernando and Jia Luo and Philip Rubin and Jeremy Henley and Kevin Wilkinson",
year = "2019",
month = "2",
day = "22",
doi = "10.1371/journal.pone.0212857",
language = "English",
volume = "14",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "2",

}

RIS - suitable for import to EndNote

TY - JOUR

T1 - Developmental profiles of SUMOylation pathway proteins in rat cerebrum and cerebellum

AU - Josa Prado, Fernando

AU - Luo, Jia

AU - Rubin, Philip

AU - Henley, Jeremy

AU - Wilkinson, Kevin

PY - 2019/2/22

Y1 - 2019/2/22

N2 - Protein SUMOylation regulates multiple processes involved in the differentiation and maturation of cells and tissues during development. Despite this, relatively little is known about the spatial and temporal regulation of proteins that mediate SUMOylation and deSUMOylation in the CNS. Here we monitor the expression of key SUMO pathway proteins and levels of substrate protein SUMOylation in the forebrain and cerebellum of Wistar rats during development. Overall, the SUMOylation machinery is more highly-expressed at E18 and decreases thereafter, as previously described. All of the proteins investigated are less abundant in adult than in embryonic brain. Furthermore, we show for first time that the profiles differ between cerebellum and cerebrum, indicating differential regional regulation of some of the proteins analysed. These data provide further basic observation that may open a new perspective of research about the role of SUMOylation in the development of different brain regions.

AB - Protein SUMOylation regulates multiple processes involved in the differentiation and maturation of cells and tissues during development. Despite this, relatively little is known about the spatial and temporal regulation of proteins that mediate SUMOylation and deSUMOylation in the CNS. Here we monitor the expression of key SUMO pathway proteins and levels of substrate protein SUMOylation in the forebrain and cerebellum of Wistar rats during development. Overall, the SUMOylation machinery is more highly-expressed at E18 and decreases thereafter, as previously described. All of the proteins investigated are less abundant in adult than in embryonic brain. Furthermore, we show for first time that the profiles differ between cerebellum and cerebrum, indicating differential regional regulation of some of the proteins analysed. These data provide further basic observation that may open a new perspective of research about the role of SUMOylation in the development of different brain regions.

U2 - 10.1371/journal.pone.0212857

DO - 10.1371/journal.pone.0212857

M3 - Article

C2 - 30794696

VL - 14

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 2

M1 - e0212857

ER -