Vascular dysfunction is a common consequence of diabetes mellitus. Stable propagation of gene expression from cell to cell during development of diseases (like diabetes) is regulated by epigenetic mechanisms. These are heritable patterns of gene expression that cannot solely be explained by changes in the DNA sequence. Recent evidence shows that diabetes-induced epigenetic changes can affect gene expression in vascular endothelial cells and vascular smooth muscles cells. Such effects further influence inflammatory and insulin production pathways (e.g. IL-8 production via the NF-κB pathway, crosstalk between cyclo-oxygenase and nitric oxide pathway etc.) leading on to an impaired insulin production in these cells. In these cells and thus ensure a long-term memory, whereby epigenetic changes are maintained even long after restoring normo-glycaemic conditions by appropriate therapeutic approaches. This review focuses on the epigenetic marks, which endure on the vascular chromatin under diabetic conditions.
|Translated title of the contribution||Diabetes-induced epigenetic signature in vascular cells|
|Journal||Endocrine, Metabolic and Immune Disorders Drug Targets|
|Publication status||Published - Jan 2012|