Diabetic Nephropathy: Perspective on Novel Molecular Mechanisms

Luigi Gnudi, Richard J.M. Coward, David A. Long

Research output: Contribution to journalArticle (Academic Journal)

103 Citations (Scopus)
315 Downloads (Pure)

Abstract

Diabetes mellitus (DM) is the major cause of end-stage renal disease (ESRD) globally, and novel treatments are urgently needed. Current therapeutic approaches for diabetic nephropathy (DN) are focussing on blood pressure control with inhibitors of the renin–angiotensin–aldosterone system, on glycaemic and lipid control, and life-style changes. In this review, we highlight new molecular insights aiding our understanding of the initiation and progression of DN, including glomerular insulin resistance, dysregulation of cellular substrate utilisation, podocyte–endothelial communication, and inhibition of tubular sodium coupled glucose reabsorption. We believe that these mechanisms offer new therapeutic targets that can be exploited to develop important renoprotective treatments for DN over the next decade.
Original languageEnglish
Pages (from-to)820-830
Number of pages11
JournalTrends in Endocrinology and Metabolism
Volume27
Issue number11
Early online date25 Jul 2016
DOIs
Publication statusPublished - 10 Nov 2016

Keywords

  • diabetes
  • glomerulus
  • oxidative stress
  • podocytes
  • endothelium
  • SGLT2

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