Diagnosis of arrhythmogenic cardiomyopathy: The Padua criteria

Domenico Corrado, Martina Perazzolo Marra, Alessandro Zorzi, Giorgia Beffagna, Alberto Cipriani, Manuel De Lazzari, Federico Migliore, Kalliopi Pilichou, Alessandra Rampazzo, Ilaria Rigato, Stefania Rizzo, Gaetano Thiene, Aris Anastasakis, Angeliki Asimaki, Chiara Bucciarelli-Ducci, Kristine H Haugaa, Francis E Marchlinski, Andrea Mazzanti, William J McKenna, Antonis PantazisAntonio Pelliccia, Christian Schmied, Sanjay Sharma, Thomas Wichter, Barbara Bauce, Cristina Basso

Research output: Contribution to journalArticle (Academic Journal)peer-review

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The original designation of "Arrhythmogenic right ventricular (dysplasia/) cardiomyopathy"(ARVC) was used by the scientists who first discovered the disease, in the pre-genetic and pre-cardiac magnetic resonance era, to describe a new heart muscle disease predominantly affecting the right ventricle, whose cardinal clinical manifestation was the occurrence of malignant ventricular arrhythmias. Subsequently, autopsy investigations, genotype-phenotype correlations studies and the increasing use of contrast-enhancement cardiac magnetic resonance showed that the fibro-fatty replacement of the myocardium represents the distinctive phenotypic feature of the disease that affects the myocardium of both ventricles, with left ventricular involvement which may parallel or exceed the severity of right ventricular involvement. This has led to the new designation of "Arrhythmogenic Cardiomyopathy" (ACM), that represents the evolution of the original term of ARVC. The present International Expert Consensus document proposes an upgrade of the criteria for diagnosis of the entire spectrum of the phenotypic variants of ACM. The proposed "Padua criteria" derive from the diagnostic approach to ACM, which has been developed over 30 years by the multidisciplinary team of basic researchers and clinical cardiologists of the Medical School of the University of Padua. The Padua criteria are a working framework to improve the diagnosis of ACM by introducing new diagnostic criteria regarding tissue characterization findings by contrast-enhanced cardiac magnetic resonance, depolarization/repolarization ECG abnormalities and ventricular arrhythmia features for diagnosis of the left ventricular phenotype. The proposed diagnostic criteria need to be further validated by future clinical studies in large cohorts of patients.

Original languageEnglish
Pages (from-to)106-114
Number of pages9
JournalInternational Journal of Cardiology
Early online date16 Jun 2020
Publication statusE-pub ahead of print - 16 Jun 2020


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