Diagnostic accuracy of post-mortem magnetic resonance imaging in fetuses, children and adults: A systematic review

Sudhin Thayyil; Manigandan Chandrasekaran; Lyn S. Chitty; Angie Wade; Jolene Skordis-Worrall; Ian Bennett-Britton; Marta Cohen; Elspeth Withby; Neil J. Sebire; Nicola J. Robertson; Andrew M. Taylor

doi:10.1016/j.ejrad.2009.10.007

Diagnostic accuracy of post-mortem magnetic resonance imaging in fetuses, children and adults: A systematic review

Sudhin Thayyil^*, Manigandan Chandrasekaran, Lyn S. Chitty, Angie Wade, Jolene Skordis-Worrall, Ian Bennett-Britton, Marta Cohen, Elspeth Withby, Neil J. Sebire, Nicola J. Robertson, Andrew M. Taylor

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

70 Citations (Scopus)

Abstract

To determine, in a systematic review, the diagnostic accuracy, acceptability and cost-effectiveness of less invasive autopsy by post-mortem MR imaging, in fetuses, children and adults. We searched Medline, Embase, the Cochrane library and reference lists to identify all studies comparing post-mortem MR imaging with conventional autopsy, published between January 1990 and March 2009. 539 abstracts were identified; 15 papers met the inclusion criteria; data from 9 studies were extracted (total: 146 fetuses, 11 children and 24 adults). In accurately identifying the final cause of death or most clinically significant abnormality, post-mortem MR imaging had a sensitivity and specificity of 69% (95% CI-56%, 80%) and 95% (95% CI-88%, 98%) in fetuses, and 28% (95% CI-13%, 47%) and 64% (95% CI-23%, 94%) in children and adults, respectively; however the published data is limited to small, heterogenous and poorly designed studies. Insufficient data is available on acceptability and economic evaluation of post-mortem MR imaging. Well designed, large, prospective studies are required to evaluate the accuracy of post-mortem MR imaging, before it can be offered as a clinical tool.

Original language	English
Pages (from-to)	e142-e148
Journal	European Journal of Radiology
Volume	75
Issue number	1
DOIs	https://doi.org/10.1016/j.ejrad.2009.10.007
Publication status	Published - Jul 2010

Bibliographical note

Funding Information:
This work was undertaken at Great Ormond Street Hospital and University College Hospital, London who received a proportion of funding from the United Kingdom Department of Health's NIHR Biomedical Research Centres funding scheme. ST is funded by the UK Department of Health and Comprehensive Biomedical Research Centre, University College Hospital. AMT is funded by the National Institute of Health Research (NIHR) (SRF/08/01/018). NJR, NJS and JSW are funded by Higher Education Funding Council for England.

Keywords

Autopsy
Costing
Economic evaluation
Magnetic resonance imaging
Parental attitudes
Sensitivity
Specificity
Systematic review

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Thayyil, S., Chandrasekaran, M., Chitty, L. S., Wade, A., Skordis-Worrall, J., Bennett-Britton, I., Cohen, M., Withby, E., Sebire, N. J., Robertson, N. J., & Taylor, A. M. (2010). Diagnostic accuracy of post-mortem magnetic resonance imaging in fetuses, children and adults: A systematic review. European Journal of Radiology, 75(1), e142-e148. https://doi.org/10.1016/j.ejrad.2009.10.007

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title = "Diagnostic accuracy of post-mortem magnetic resonance imaging in fetuses, children and adults: A systematic review",

abstract = "To determine, in a systematic review, the diagnostic accuracy, acceptability and cost-effectiveness of less invasive autopsy by post-mortem MR imaging, in fetuses, children and adults. We searched Medline, Embase, the Cochrane library and reference lists to identify all studies comparing post-mortem MR imaging with conventional autopsy, published between January 1990 and March 2009. 539 abstracts were identified; 15 papers met the inclusion criteria; data from 9 studies were extracted (total: 146 fetuses, 11 children and 24 adults). In accurately identifying the final cause of death or most clinically significant abnormality, post-mortem MR imaging had a sensitivity and specificity of 69% (95% CI-56%, 80%) and 95% (95% CI-88%, 98%) in fetuses, and 28% (95% CI-13%, 47%) and 64% (95% CI-23%, 94%) in children and adults, respectively; however the published data is limited to small, heterogenous and poorly designed studies. Insufficient data is available on acceptability and economic evaluation of post-mortem MR imaging. Well designed, large, prospective studies are required to evaluate the accuracy of post-mortem MR imaging, before it can be offered as a clinical tool.",

keywords = "Autopsy, Costing, Economic evaluation, Magnetic resonance imaging, Parental attitudes, Sensitivity, Specificity, Systematic review",

author = "Sudhin Thayyil and Manigandan Chandrasekaran and Chitty, {Lyn S.} and Angie Wade and Jolene Skordis-Worrall and Ian Bennett-Britton and Marta Cohen and Elspeth Withby and Sebire, {Neil J.} and Robertson, {Nicola J.} and Taylor, {Andrew M.}",

note = "Funding Information: This work was undertaken at Great Ormond Street Hospital and University College Hospital, London who received a proportion of funding from the United Kingdom Department of Health's NIHR Biomedical Research Centres funding scheme. ST is funded by the UK Department of Health and Comprehensive Biomedical Research Centre, University College Hospital. AMT is funded by the National Institute of Health Research (NIHR) (SRF/08/01/018). NJR, NJS and JSW are funded by Higher Education Funding Council for England. ",

year = "2010",

month = jul,

doi = "10.1016/j.ejrad.2009.10.007",

language = "English",

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Thayyil, S, Chandrasekaran, M, Chitty, LS, Wade, A, Skordis-Worrall, J, Bennett-Britton, I, Cohen, M, Withby, E, Sebire, NJ, Robertson, NJ & Taylor, AM 2010, 'Diagnostic accuracy of post-mortem magnetic resonance imaging in fetuses, children and adults: A systematic review', European Journal of Radiology, vol. 75, no. 1, pp. e142-e148. https://doi.org/10.1016/j.ejrad.2009.10.007

TY - JOUR

T1 - Diagnostic accuracy of post-mortem magnetic resonance imaging in fetuses, children and adults

T2 - A systematic review

AU - Thayyil, Sudhin

AU - Chandrasekaran, Manigandan

AU - Chitty, Lyn S.

AU - Wade, Angie

AU - Skordis-Worrall, Jolene

AU - Bennett-Britton, Ian

AU - Cohen, Marta

AU - Withby, Elspeth

AU - Sebire, Neil J.

AU - Robertson, Nicola J.

AU - Taylor, Andrew M.

N1 - Funding Information: This work was undertaken at Great Ormond Street Hospital and University College Hospital, London who received a proportion of funding from the United Kingdom Department of Health's NIHR Biomedical Research Centres funding scheme. ST is funded by the UK Department of Health and Comprehensive Biomedical Research Centre, University College Hospital. AMT is funded by the National Institute of Health Research (NIHR) (SRF/08/01/018). NJR, NJS and JSW are funded by Higher Education Funding Council for England.

PY - 2010/7

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N2 - To determine, in a systematic review, the diagnostic accuracy, acceptability and cost-effectiveness of less invasive autopsy by post-mortem MR imaging, in fetuses, children and adults. We searched Medline, Embase, the Cochrane library and reference lists to identify all studies comparing post-mortem MR imaging with conventional autopsy, published between January 1990 and March 2009. 539 abstracts were identified; 15 papers met the inclusion criteria; data from 9 studies were extracted (total: 146 fetuses, 11 children and 24 adults). In accurately identifying the final cause of death or most clinically significant abnormality, post-mortem MR imaging had a sensitivity and specificity of 69% (95% CI-56%, 80%) and 95% (95% CI-88%, 98%) in fetuses, and 28% (95% CI-13%, 47%) and 64% (95% CI-23%, 94%) in children and adults, respectively; however the published data is limited to small, heterogenous and poorly designed studies. Insufficient data is available on acceptability and economic evaluation of post-mortem MR imaging. Well designed, large, prospective studies are required to evaluate the accuracy of post-mortem MR imaging, before it can be offered as a clinical tool.

AB - To determine, in a systematic review, the diagnostic accuracy, acceptability and cost-effectiveness of less invasive autopsy by post-mortem MR imaging, in fetuses, children and adults. We searched Medline, Embase, the Cochrane library and reference lists to identify all studies comparing post-mortem MR imaging with conventional autopsy, published between January 1990 and March 2009. 539 abstracts were identified; 15 papers met the inclusion criteria; data from 9 studies were extracted (total: 146 fetuses, 11 children and 24 adults). In accurately identifying the final cause of death or most clinically significant abnormality, post-mortem MR imaging had a sensitivity and specificity of 69% (95% CI-56%, 80%) and 95% (95% CI-88%, 98%) in fetuses, and 28% (95% CI-13%, 47%) and 64% (95% CI-23%, 94%) in children and adults, respectively; however the published data is limited to small, heterogenous and poorly designed studies. Insufficient data is available on acceptability and economic evaluation of post-mortem MR imaging. Well designed, large, prospective studies are required to evaluate the accuracy of post-mortem MR imaging, before it can be offered as a clinical tool.

KW - Autopsy

KW - Costing

KW - Economic evaluation

KW - Magnetic resonance imaging

KW - Parental attitudes

KW - Sensitivity

KW - Specificity

KW - Systematic review

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DO - 10.1016/j.ejrad.2009.10.007

M3 - Article (Academic Journal)

C2 - 19910149

AN - SCOPUS:77953958434

SN - 0720-048X

VL - 75

SP - e142-e148

JO - European Journal of Radiology

JF - European Journal of Radiology

IS - 1

ER -

Diagnostic accuracy of post-mortem magnetic resonance imaging in fetuses, children and adults: A systematic review

Abstract

Bibliographical note

Keywords

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