Diagnostic accuracy of two point-of-care kits for the diagnosis of Giardia species infection in dogs: Accuracy of two POCT for diagnosis of Giardia species

Marta Costa, Christine Clarke, Sharon Mitchell, Kostas Papasouliotis

Research output: Contribution to journalArticle (Academic Journal)peer-review

7 Citations (Scopus)

Abstract

OBJECTIVES The objective of this study was to compare results obtained by ZnSO4 Flotation and SNAP ®Giardia to those generated by the new point‐of‐care tests Single and Triple Rapid. METHODS Prospective study evaluating 51 canine faecal samples submitted at a reference laboratory for the presence of Giardia spp. Kappa statistics, specificity, sensitivity, positive predictive value (PPV) and negative predictive value (NPV) were calculated by comparing the new tests to the combined results of ZnSO4 and SNAP tests. RESULTS There was fair (Single Rapid, j=0·434) to good (Triple Rapid, j =0·797) agreement with the reference tests. At this study's prevalence (59 to 61%), specificities and PPV were high (1·00) with both Rapid tests, but sensitivities and NPV were lower for the Single than for the Triple (0·48 vs 0·83 and 0·55 vs 0·80) tests. At lower prevalence rates, both tests exhibited a high PPV (1·00), but the NPV were higher with the Triple (0·96 to 0·99) than the Single (0·88 to 0·96) Rapid test. CLINICAL SIGNIFICANCE Both tests exhibited excellent PPV values at all prevalence rates but an excellent NPV only at low prevalence. As the prevalence is likely to be low (<15%) in clinical settings, we propose that these tests may be helpful in the in‐house diagnosis of Giardia spp infection. However, they exhibit lower sensitivity than the combined sensitivity of ZnSO4 and SNAP tests, particularly in high prevalence settings.
Original languageEnglish
Pages (from-to)318-322
Number of pages5
JournalJournal of Small Animal Practice
Volume57
Issue number6
Early online date1 Jun 2016
DOIs
Publication statusPublished - Jun 2016

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