Diagnostic MALDI-TOF MS can differentiate between high and low toxic Staphylococcus aureus bacteraemia isolates as a predictor of patient outcome

Tarcisio Brignoli, Mario Recker, Winnie W.Y. Lee, Tim Dong, Ranjeet Bhamber, Mahableshwar Albur, Philip Williams, Andrew W. Dowsey, Ruth C. Massey*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

1 Citation (Scopus)
109 Downloads (Pure)

Abstract

Staphylococcus aureus bacteraemia (SAB) is a major cause of blood-stream infection (BSI) in both healthcare and community settings. While the underlying comorbidities of a patient significantly contributes to their susceptibility to and outcome following SAB, recent studies show the importance of the level of cytolytic toxin production by the infecting bacterium. In this study we demonstrate that this cytotoxicity can be determined directly from the diagnostic MALDI-TOF mass spectrum generated in a routine diagnostic laboratory. With further development this information could be used to guide the management and improve the outcomes for SAB patients.

Original languageEnglish
Article number001223
Number of pages6
JournalMicrobiology
Volume168
Issue number8
DOIs
Publication statusPublished - 23 Aug 2022

Bibliographical note

Funding Information:
This work was funded by a Wellcome Trust funded Investigator awarded to RCM (Grant reference number: 212258/Z/18/Z), The Showering Fund award (SF124) awarded to MA, an MRC grant (MR/T005408/1) awarded to PW, and the Health Data Research UK South-West Better Care Partnership AMR Site Project, lead AWD. Health Data Research UK is an initiative funded by UK Research and Innovation, Department of Health and Social Care (England) and the devolved administrations, and leading medical research charities.

Publisher Copyright:
© 2022, Microbiology Society. All rights reserved.

Keywords

  • bacteraemia
  • Agr
  • MALDI-TOF MS diagnosis
  • Staphylococcus aureus
  • toxicity

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