Abstract
Staphylococcus aureus bacteraemia (SAB) is a major cause of blood-stream infection (BSI) in both healthcare and community settings. While the underlying comorbidities of a patient significantly contributes to their susceptibility to and outcome following SAB, recent studies show the importance of the level of cytolytic toxin production by the infecting bacterium. In this study we demonstrate that this cytotoxicity can be determined directly from the diagnostic MALDI-TOF mass spectrum generated in a routine diagnostic laboratory. With further development this information could be used to guide the management and improve the outcomes for SAB patients.
Original language | English |
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Article number | 001223 |
Number of pages | 6 |
Journal | Microbiology |
Volume | 168 |
Issue number | 8 |
DOIs | |
Publication status | Published - 23 Aug 2022 |
Bibliographical note
Funding Information:This work was funded by a Wellcome Trust funded Investigator awarded to RCM (Grant reference number: 212258/Z/18/Z), The Showering Fund award (SF124) awarded to MA, an MRC grant (MR/T005408/1) awarded to PW, and the Health Data Research UK South-West Better Care Partnership AMR Site Project, lead AWD. Health Data Research UK is an initiative funded by UK Research and Innovation, Department of Health and Social Care (England) and the devolved administrations, and leading medical research charities.
Publisher Copyright:
© 2022, Microbiology Society. All rights reserved.
Keywords
- bacteraemia
- Agr
- MALDI-TOF MS diagnosis
- Staphylococcus aureus
- toxicity