Diastereomeric ratio determination by high sensitivity band-selective pure shift NMR spectroscopy

Ralph W. Adams; Liam Byrne; Péter Király; Mohammadali Foroozandeh; Liladhar Paudel; Mathias Nilsson; Jonathan Clayden; Gareth A. Morris

doi:10.1039/c3cc49659g

Diastereomeric ratio determination by high sensitivity band-selective pure shift NMR spectroscopy

Ralph W. Adams, Liam Byrne, Péter Király, Mohammadali Foroozandeh, Liladhar Paudel, Mathias Nilsson, Jonathan Clayden, Gareth A. Morris^*

^*Corresponding author for this work

School of Chemistry

Research output: Contribution to journal › Article (Academic Journal) › peer-review

56 Citations (Scopus)

Abstract

An NMR method is reported that allows diastereomeric ratios to be determined even in crowded spectra or where chemical shift differences are small compared to multiplet widths. Band-selective pure shift NMR collapses multiplets to singlets, greatly improving spectral resolution while largely retaining, or even enhancing, signal-to-noise ratio.

Original language	English
Pages (from-to)	2512-2514
Number of pages	3
Journal	Chemical Communications
Volume	50
Issue number	19
Early online date	16 Jan 2014
DOIs	https://doi.org/10.1039/c3cc49659g
Publication status	Published - 7 Mar 2014

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10.1039/c3cc49659g

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abstract = "An NMR method is reported that allows diastereomeric ratios to be determined even in crowded spectra or where chemical shift differences are small compared to multiplet widths. Band-selective pure shift NMR collapses multiplets to singlets, greatly improving spectral resolution while largely retaining, or even enhancing, signal-to-noise ratio.",

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Diastereomeric ratio determination by high sensitivity band-selective pure shift NMR spectroscopy. / Adams, Ralph W.; Byrne, Liam; Király, Péter; Foroozandeh, Mohammadali; Paudel, Liladhar; Nilsson, Mathias; Clayden, Jonathan; Morris, Gareth A.

In: Chemical Communications, Vol. 50, No. 19, 07.03.2014, p. 2512-2514.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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T1 - Diastereomeric ratio determination by high sensitivity band-selective pure shift NMR spectroscopy

AU - Adams, Ralph W.

AU - Byrne, Liam

AU - Király, Péter

AU - Foroozandeh, Mohammadali

AU - Paudel, Liladhar

AU - Nilsson, Mathias

AU - Clayden, Jonathan

AU - Morris, Gareth A.

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AB - An NMR method is reported that allows diastereomeric ratios to be determined even in crowded spectra or where chemical shift differences are small compared to multiplet widths. Band-selective pure shift NMR collapses multiplets to singlets, greatly improving spectral resolution while largely retaining, or even enhancing, signal-to-noise ratio.

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