Dibenzazepinyl ureas as dual NMR and CD probes of helical screw-sense preference in conformationally equilibrating dynamic foldamers

Vincent Diemer, Julien Maury, Bryden A.F. Le Bailly, Simon J. Webb, Jonathan Clayden*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)

4 Citations (Scopus)
234 Downloads (Pure)

Abstract

Conformationally mobile oligomers with helical structures, or 'dynamic foldamers', may populate a mixture of screw-sense conformers whose relative proportion has been used as a means of communicating information on a molecular scale. The dibenzazepinyl urea provides a means of quantifying both the sense and degree of this screw-sense preference through a combination of circular dichroism (CD) and NMR spectroscopy. The dibenzazepinyl urea probe is synthetically versatile, readily accessible, and easy to introduce to the terminus of an amide or a urea foldamer.

Original languageEnglish
Pages (from-to)10768-10771
Number of pages4
JournalChemical Communications
Volume53
Issue number78
Early online date31 Aug 2017
DOIs
Publication statusPublished - 7 Oct 2017

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