Dichloromeldrum’s Acid (DiCMA): A Practical and Green Amine Dichloroacetylation Reagent

David M Heard, Alastair J J Lennox*

*Corresponding author for this work

Research output: Contribution to journalLetter (Academic Journal)peer-review

3 Citations (Scopus)
64 Downloads (Pure)


Dichloromeldrum’s acid is introduced as a bench-stable, nonvolatile reagent for the dichloroacetylation of anilines and alkyl amines to produce α,α-dichloroacetamides, which are important motifs for medicinal chemistry. Products are formed in good to excellent yields with reagent grade solvents, and, as the only byproducts are acetone and CO2, no column chromatography is required. Thus, this reagent is practical, efficient, and green for the dichloroacetylation of primary amines.
Original languageEnglish
Pages (from-to)3368-3372
Number of pages5
JournalOrganic Letters
Issue number9
Early online date12 Apr 2021
Publication statusPublished - 7 May 2021

Bibliographical note

Funding Information:
We would like to thank the Royal Society (University Research Fellowship and Enhancement award to A.J.J.L.) and EPSRC (EP/T001631/1) for funding.

Publisher Copyright:
© 2021 American Chemical Society.


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