Dichloromeldrum’s acid is introduced as a bench-stable, nonvolatile reagent for the dichloroacetylation of anilines and alkyl amines to produce α,α-dichloroacetamides, which are important motifs for medicinal chemistry. Products are formed in good to excellent yields with reagent grade solvents, and, as the only byproducts are acetone and CO2, no column chromatography is required. Thus, this reagent is practical, efficient, and green for the dichloroacetylation of primary amines.
Bibliographical noteFunding Information:
We would like to thank the Royal Society (University Research Fellowship and Enhancement award to A.J.J.L.) and EPSRC (EP/T001631/1) for funding.
© 2021 American Chemical Society.