Diet or diet plus physical activity versus usual care in patients with newly diagnosed type 2 diabetes: the Early ACTID randomised controlled trial

R. C. Andrews; A. R. Cooper; A. A. Montgomery; Alastair J Norcross; T. J. Peters; D. J. Sharp; N Jackson; K Fitzsimons; J Bright; Karen D Coulman; Clare Y England; Janet G Gorton; Amanda J McLenaghan; Elizabeth C Paxton; Anne Polet; Catherine A Thompson; C. M. Dayan

doi:10.1016/S0140-6736(11)60442-X

Diet or diet plus physical activity versus usual care in patients with newly diagnosed type 2 diabetes: the Early ACTID randomised controlled trial

R. C. Andrews, A. R. Cooper, A. A. Montgomery, Alastair J Norcross, T. J. Peters, D. J. Sharp, N Jackson, K Fitzsimons, J Bright, Karen D Coulman, Clare Y England, Janet G Gorton, Amanda J McLenaghan, Elizabeth C Paxton, Anne Polet, Catherine A Thompson, C. M. Dayan

Research output: Contribution to journal › Article (Academic Journal)

172 Citations (Scopus)

Abstract

BACKGROUND: Lifestyle changes soon after diagnosis might improve outcomes in patients with type 2 diabetes mellitus, but no large trials have compared interventions. We investigated the effects of diet and physical activity on blood pressure and glucose concentrations. METHODS: We did a randomised, controlled trial in southwest England in adults aged 30-80 years in whom type 2 diabetes had been diagnosed 5-8 months previously. Participants were assigned usual care (initial dietary consultation and follow-up every 6 months; control group), an intensive diet intervention (dietary consultation every 3 months with monthly nurse support), or the latter plus a pedometer-based activity programme, in a 2:5:5 ratio. The primary endpoint was improvement in glycated haemoglobin A(1c)(HbA(1c)) concentration and blood pressure at 6 months. Analysis was done by intention to treat. This study is registered, number ISRCTN92162869. FINDINGS: Of 593 eligible individuals, 99 were assigned usual care, 248 the diet regimen, and 246 diet plus activity. Outcome data were available for 587 (99%) and 579 (98%) participants at 6 and 12 months, respectively. At 6 months, glycaemic control had worsened in the control group (mean baseline HbA(1c) percentage 6·72, SD 1·02, and at 6 months 6·86, 1·02) but improved in the diet group (baseline-adjusted difference in percentage of HbA(1c) -0·28%, 95% CI -0·46 to -0·10; p=0·005) and diet plus activity group (-0·33%, -0·51 to -0·14; p

Original language	English
Pages (from-to)	129 - 139
Number of pages	11
Journal	Lancet
Volume	378
Issue number	9786
DOIs	https://doi.org/10.1016/S0140-6736(11)60442-X
Publication status	Published - 25 Jun 2011

Access to Document

10.1016/S0140-6736(11)60442-X

Fingerprint Dive into the research topics of 'Diet or diet plus physical activity versus usual care in patients with newly diagnosed type 2 diabetes: the Early ACTID randomised controlled trial'. Together they form a unique fingerprint.

Projects

1 Finished
1 Active

Early ACTID : Early Activity In Diabetes

Cooper, A. R., Andrews, R. C., Dayan, C. M., Sharp, D. J., Peters, T. & Montgomery, A. A.

1/06/04 → …

Project: Research

COLLABORATION AND INNOVATION IN DIFFICULT OR RANDOMISED CONTROLLED TRIALS

Blazeby, J. M.

1/04/09 → 1/04/14

Project: Research

Cite this

Andrews, R. C., Cooper, A. R., Montgomery, A. A., Norcross, A. J., Peters, T. J., Sharp, D. J., Jackson, N., Fitzsimons, K., Bright, J., Coulman, K. D., England, C. Y., Gorton, J. G., McLenaghan, A. J., Paxton, E. C., Polet, A., Thompson, C. A., & Dayan, C. M. (2011). Diet or diet plus physical activity versus usual care in patients with newly diagnosed type 2 diabetes: the Early ACTID randomised controlled trial. Lancet, 378(9786), 129 - 139. https://doi.org/10.1016/S0140-6736(11)60442-X

Andrews, R. C. ; Cooper, A. R. ; Montgomery, A. A. ; Norcross, Alastair J ; Peters, T. J. ; Sharp, D. J. ; Jackson, N ; Fitzsimons, K ; Bright, J ; Coulman, Karen D ; England, Clare Y ; Gorton, Janet G ; McLenaghan, Amanda J ; Paxton, Elizabeth C ; Polet, Anne ; Thompson, Catherine A ; Dayan, C. M. / Diet or diet plus physical activity versus usual care in patients with newly diagnosed type 2 diabetes: the Early ACTID randomised controlled trial. In: Lancet. 2011 ; Vol. 378, No. 9786. pp. 129 - 139.

@article{902f214ae15445ba8b7c058daba21c26,

title = "Diet or diet plus physical activity versus usual care in patients with newly diagnosed type 2 diabetes: the Early ACTID randomised controlled trial",

abstract = "BACKGROUND: Lifestyle changes soon after diagnosis might improve outcomes in patients with type 2 diabetes mellitus, but no large trials have compared interventions. We investigated the effects of diet and physical activity on blood pressure and glucose concentrations. METHODS: We did a randomised, controlled trial in southwest England in adults aged 30-80 years in whom type 2 diabetes had been diagnosed 5-8 months previously. Participants were assigned usual care (initial dietary consultation and follow-up every 6 months; control group), an intensive diet intervention (dietary consultation every 3 months with monthly nurse support), or the latter plus a pedometer-based activity programme, in a 2:5:5 ratio. The primary endpoint was improvement in glycated haemoglobin A(1c)(HbA(1c)) concentration and blood pressure at 6 months. Analysis was done by intention to treat. This study is registered, number ISRCTN92162869. FINDINGS: Of 593 eligible individuals, 99 were assigned usual care, 248 the diet regimen, and 246 diet plus activity. Outcome data were available for 587 (99%) and 579 (98%) participants at 6 and 12 months, respectively. At 6 months, glycaemic control had worsened in the control group (mean baseline HbA(1c) percentage 6·72, SD 1·02, and at 6 months 6·86, 1·02) but improved in the diet group (baseline-adjusted difference in percentage of HbA(1c) -0·28%, 95% CI -0·46 to -0·10; p=0·005) and diet plus activity group (-0·33%, -0·51 to -0·14; p",

author = "Andrews, {R. C.} and Cooper, {A. R.} and Montgomery, {A. A.} and Norcross, {Alastair J} and Peters, {T. J.} and Sharp, {D. J.} and N Jackson and K Fitzsimons and J Bright and Coulman, {Karen D} and England, {Clare Y} and Gorton, {Janet G} and McLenaghan, {Amanda J} and Paxton, {Elizabeth C} and Anne Polet and Thompson, {Catherine A} and Dayan, {C. M.}",

year = "2011",

month = jun,

day = "25",

doi = "10.1016/S0140-6736(11)60442-X",

language = "English",

volume = "378",

pages = "129 -- 139",

journal = "Lancet",

issn = "0140-6736",

publisher = "Lancet Publishing Group",

number = "9786",

}

Andrews, RC, Cooper, AR, Montgomery, AA, Norcross, AJ, Peters, TJ , Sharp, DJ, Jackson, N, Fitzsimons, K, Bright, J, Coulman, KD , England, CY, Gorton, JG, McLenaghan, AJ, Paxton, EC, Polet, A, Thompson, CA & Dayan, CM 2011, 'Diet or diet plus physical activity versus usual care in patients with newly diagnosed type 2 diabetes: the Early ACTID randomised controlled trial', Lancet, vol. 378, no. 9786, pp. 129 - 139. https://doi.org/10.1016/S0140-6736(11)60442-X

Diet or diet plus physical activity versus usual care in patients with newly diagnosed type 2 diabetes: the Early ACTID randomised controlled trial. / Andrews, R. C.; Cooper, A. R.; Montgomery, A. A.; Norcross, Alastair J; Peters, T. J.; Sharp, D. J.; Jackson, N; Fitzsimons, K; Bright, J; Coulman, Karen D ; England, Clare Y; Gorton, Janet G; McLenaghan, Amanda J; Paxton, Elizabeth C; Polet, Anne; Thompson, Catherine A; Dayan, C. M.

In: Lancet, Vol. 378, No. 9786, 25.06.2011, p. 129 - 139.

Research output: Contribution to journal › Article (Academic Journal)

TY - JOUR

T1 - Diet or diet plus physical activity versus usual care in patients with newly diagnosed type 2 diabetes: the Early ACTID randomised controlled trial

AU - Andrews, R. C.

AU - Cooper, A. R.

AU - Montgomery, A. A.

AU - Norcross, Alastair J

AU - Peters, T. J.

AU - Sharp, D. J.

AU - Jackson, N

AU - Fitzsimons, K

AU - Bright, J

AU - Coulman, Karen D

AU - England, Clare Y

AU - Gorton, Janet G

AU - McLenaghan, Amanda J

AU - Paxton, Elizabeth C

AU - Polet, Anne

AU - Thompson, Catherine A

AU - Dayan, C. M.

PY - 2011/6/25

Y1 - 2011/6/25

N2 - BACKGROUND: Lifestyle changes soon after diagnosis might improve outcomes in patients with type 2 diabetes mellitus, but no large trials have compared interventions. We investigated the effects of diet and physical activity on blood pressure and glucose concentrations. METHODS: We did a randomised, controlled trial in southwest England in adults aged 30-80 years in whom type 2 diabetes had been diagnosed 5-8 months previously. Participants were assigned usual care (initial dietary consultation and follow-up every 6 months; control group), an intensive diet intervention (dietary consultation every 3 months with monthly nurse support), or the latter plus a pedometer-based activity programme, in a 2:5:5 ratio. The primary endpoint was improvement in glycated haemoglobin A(1c)(HbA(1c)) concentration and blood pressure at 6 months. Analysis was done by intention to treat. This study is registered, number ISRCTN92162869. FINDINGS: Of 593 eligible individuals, 99 were assigned usual care, 248 the diet regimen, and 246 diet plus activity. Outcome data were available for 587 (99%) and 579 (98%) participants at 6 and 12 months, respectively. At 6 months, glycaemic control had worsened in the control group (mean baseline HbA(1c) percentage 6·72, SD 1·02, and at 6 months 6·86, 1·02) but improved in the diet group (baseline-adjusted difference in percentage of HbA(1c) -0·28%, 95% CI -0·46 to -0·10; p=0·005) and diet plus activity group (-0·33%, -0·51 to -0·14; p

AB - BACKGROUND: Lifestyle changes soon after diagnosis might improve outcomes in patients with type 2 diabetes mellitus, but no large trials have compared interventions. We investigated the effects of diet and physical activity on blood pressure and glucose concentrations. METHODS: We did a randomised, controlled trial in southwest England in adults aged 30-80 years in whom type 2 diabetes had been diagnosed 5-8 months previously. Participants were assigned usual care (initial dietary consultation and follow-up every 6 months; control group), an intensive diet intervention (dietary consultation every 3 months with monthly nurse support), or the latter plus a pedometer-based activity programme, in a 2:5:5 ratio. The primary endpoint was improvement in glycated haemoglobin A(1c)(HbA(1c)) concentration and blood pressure at 6 months. Analysis was done by intention to treat. This study is registered, number ISRCTN92162869. FINDINGS: Of 593 eligible individuals, 99 were assigned usual care, 248 the diet regimen, and 246 diet plus activity. Outcome data were available for 587 (99%) and 579 (98%) participants at 6 and 12 months, respectively. At 6 months, glycaemic control had worsened in the control group (mean baseline HbA(1c) percentage 6·72, SD 1·02, and at 6 months 6·86, 1·02) but improved in the diet group (baseline-adjusted difference in percentage of HbA(1c) -0·28%, 95% CI -0·46 to -0·10; p=0·005) and diet plus activity group (-0·33%, -0·51 to -0·14; p

UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-79960268164&partnerID=8YFLogxK

U2 - 10.1016/S0140-6736(11)60442-X

DO - 10.1016/S0140-6736(11)60442-X

M3 - Article (Academic Journal)

VL - 378

SP - 129

EP - 139

JO - Lancet

JF - Lancet

SN - 0140-6736

IS - 9786

ER -