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Abstract
BACKGROUND: Lifestyle changes soon after diagnosis might improve outcomes in patients with type 2 diabetes mellitus, but no large trials have compared interventions. We investigated the effects of diet and physical activity on blood pressure and glucose concentrations.
METHODS: We did a randomised, controlled trial in southwest England in adults aged 30-80 years in whom type 2 diabetes had been diagnosed 5-8 months previously. Participants were assigned usual care (initial dietary consultation and follow-up every 6 months; control group), an intensive diet intervention (dietary consultation every 3 months with monthly nurse support), or the latter plus a pedometer-based activity programme, in a 2:5:5 ratio. The primary endpoint was improvement in glycated haemoglobin A(1c)(HbA(1c)) concentration and blood pressure at 6 months. Analysis was done by intention to treat. This study is registered, number ISRCTN92162869.
FINDINGS: Of 593 eligible individuals, 99 were assigned usual care, 248 the diet regimen, and 246 diet plus activity. Outcome data were available for 587 (99%) and 579 (98%) participants at 6 and 12 months, respectively. At 6 months, glycaemic control had worsened in the control group (mean baseline HbA(1c) percentage 6·72, SD 1·02, and at 6 months 6·86, 1·02) but improved in the diet group (baseline-adjusted difference in percentage of HbA(1c) -0·28%, 95% CI -0·46 to -0·10; p=0·005) and diet plus activity group (-0·33%, -0·51 to -0·14; p
Translated title of the contribution | Diet or diet plus physical activity versus usual care in patients with newly diagnosed type 2 diabetes: the Early ACTID randomised controlled trial |
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Original language | English |
Pages (from-to) | 129 - 139 |
Number of pages | 11 |
Journal | Lancet |
Volume | 378 |
Issue number | 9786 |
DOIs | |
Publication status | Published - 25 Jun 2011 |
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Early ACTID : Early Activity In Diabetes
Cooper, A. R. (Co-Principal Investigator), Andrews, R. C. (Co-Principal Investigator), Dayan, C. M. (Co-Investigator), Sharp, D. J. (Co-Investigator), Peters, T. (Co-Investigator) & Montgomery, A. A. (Co-Investigator)
1/06/04 → …
Project: Research
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COLLABORATION AND INNOVATION IN DIFFICULT OR RANDOMISED CONTROLLED TRIALS
Blazeby, J. (Principal Investigator)
1/04/09 → 1/04/14
Project: Research