Dietary behaviors and survival in people with head and neck cancer: Results from Head and Neck 5000

Samantha Lang*, Sarah Schimansky, Rhona Beynon, Christopher Penfold, Amy Davies, Andrea Waylen, Steven Thomas, Miranda Pring, Michael Pawlita, Tim Waterboer, Andrew R. Ness

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)

1 Citation (Scopus)
88 Downloads (Pure)

Abstract

BACKGROUND: The association between diet and head and neck cancer (HNC) survival is unclear.

METHODS: Cox proportional hazard models measured the association between fruit, vegetable, and deep-fried food intake and HNC overall survival adjusting for clinical, social and lifestyle variables including smoking, alcohol, and HPV status.

RESULTS: Fruit and vegetable intake and improved survival were associated in minimally adjusted analyses. Following adjustment for smoking and alcohol consumption (fully adjusted analyses), the association with survival disappeared for fruit (HR 0.91, 95% CI 0.67, 1.23; P for trend = .55) and attenuated for vegetables (HR 0.79, 95% CI 0.61, 1.03; P for trend = .04). We observed no association between survival and deep-fried food intake in minimally adjusted or fully adjusted analyses (HR 0.88 95% CI 0.72, 1.07; P for trend = .13).

CONCLUSIONS: Vegetable intake and HNC survival are modestly associated. There is some confounding by tobacco and alcohol consumption.

Original languageEnglish
Pages (from-to)2074-2084
Number of pages11
JournalHead and Neck
Volume41
Issue number7
Early online date30 Jan 2019
DOIs
Publication statusPublished - 1 Jul 2019

Bibliographical note

© 2019 Wiley Periodicals, Inc.

Structured keywords

  • ICEP

Keywords

  • deep-fried food
  • fruit
  • head and neck cancers
  • survival
  • vegetables

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