Abstract
Background and aim: The role of dietary protein and glycemic index on insulin resistance (based on TyG index) within a nutritional program for weight loss and weight maintenance was examined.
Methods: This study analyzed 744 adults with overweight/obesity within the DIOGenes project. Patients who lost at least 8% of their initial weight (0-8 weeks) after a low-calorie diet (LCD) were randomly assigned to one of five ad libitum diets designed for weight maintenance (8-34 weeks): high/low protein (HP/LP) and high/low glycemic index (HGI/LGI), plus a control. The complete nutritional program (0-34 weeks) included both LCD plus the randomized diets intervention. The TyG index was tested as marker of body mass composition and insulin resistance.
Results: In comparison with the LP/HGI diet, the HP/LGI diet induced a greater BMI loss (P<0.05). ∆TyGwas positively associated with resistance to BMI loss (β=0.343, p=0.042) during the weight maintenance stage. In patients who followed the HP/LGI diet, TyG (after LCD) correlated with greater BMI loss in the 8-34 weeks period (r =-0.256; p<0.05) and during the 0-34 weeks intervention (r =-0.222, p<0.05) periods.ΔTyG1 value was associated with ΔBMI2 (β= 0.932; p= 0.045) concerning the HP/LGI diet.
Conclusions:A HP/LGI diet is beneficial not only for weight maintenance after a LCD, but isalso related to IR amelioration as assessed by TyG index changes.Registration Clinical Trials NCT00390637.
Methods: This study analyzed 744 adults with overweight/obesity within the DIOGenes project. Patients who lost at least 8% of their initial weight (0-8 weeks) after a low-calorie diet (LCD) were randomly assigned to one of five ad libitum diets designed for weight maintenance (8-34 weeks): high/low protein (HP/LP) and high/low glycemic index (HGI/LGI), plus a control. The complete nutritional program (0-34 weeks) included both LCD plus the randomized diets intervention. The TyG index was tested as marker of body mass composition and insulin resistance.
Results: In comparison with the LP/HGI diet, the HP/LGI diet induced a greater BMI loss (P<0.05). ∆TyGwas positively associated with resistance to BMI loss (β=0.343, p=0.042) during the weight maintenance stage. In patients who followed the HP/LGI diet, TyG (after LCD) correlated with greater BMI loss in the 8-34 weeks period (r =-0.256; p<0.05) and during the 0-34 weeks intervention (r =-0.222, p<0.05) periods.ΔTyG1 value was associated with ΔBMI2 (β= 0.932; p= 0.045) concerning the HP/LGI diet.
Conclusions:A HP/LGI diet is beneficial not only for weight maintenance after a LCD, but isalso related to IR amelioration as assessed by TyG index changes.Registration Clinical Trials NCT00390637.
| Original language | English |
|---|---|
| Article number | 71 |
| Pages (from-to) | 1-15 |
| Journal | Nutrition & Metabolism |
| Volume | 19 |
| Issue number | 71 |
| DOIs | |
| Publication status | Published - 19 Oct 2022 |
Research Groups and Themes
- SPS Exercise, Nutrition and Health Sciences
Keywords
- Insulin resistance
- TyG index
- Protein diet
- glycemic index
- metabolic improvement
- precision nutrition
Access to Document
- Full-text PDF (Final published version)
This is the final published version of the article (version of record). It first appeared online via BMC at https://doi.org/10.1186/s12986-022-00707-y. Please refer to any applicable terms of use of the publisher.