Dietary quality and dietary inflammatory potential during pregnancy and offspring emotional and behavioral symptoms in childhood: an individual participant data metaanalysis of four European cohorts

Kinga Polanska; Pawel Kalunzy; Adrien M Aubert; Jonathan Y Bernard; Liesbeth Duijts; Hanan El Marrroun; Wojciech Hanke; James R Hébert; Barbara Heude; A Jankowska; Giulia Mancano; Sara M Mensink-Bout; Caroline L Relton; Nitin Shivappa; Matthew J Suderman; E Trafalska; Ewelina Wesoloska; R Garcia-Esteban; Catherine M Phillips

doi:10.1016/j.biopsych.2020.10.008

Dietary quality and dietary inflammatory potential during pregnancy and offspring emotional and behavioral symptoms in childhood: an individual participant data metaanalysis of four European cohorts

Kinga Polanska^*, Pawel Kalunzy, Adrien M Aubert, Jonathan Y Bernard, Liesbeth Duijts, Hanan El Marrroun, Wojciech Hanke, James R Hébert, Barbara Heude, A Jankowska, Giulia Mancano, Sara M Mensink-Bout, Caroline L Relton, Nitin Shivappa, Matthew J Suderman, E Trafalska, Ewelina Wesoloska, R Garcia-Esteban, Catherine M Phillips

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

Background
The impact of maternal diet during pregnancy on child neurodevelopment is of public health and clinical relevance. We evaluated associations of dietary quality (based on Dietary Approaches to Stop Hypertension (DASH) score) and dietary inflammatory potential (based on energy-adjusted Dietary Inflammatory Index (E-DII) score) during pregnancy with offspring emotional and behavioral symptoms at 7-10 years of age.

Methods
Individual participant data for 11,870 mother-child pairs from four European cohorts participating in ALPHABET project were analyzed. Maternal antenatal DASH and E-DII scores were generated from self-completed food frequency questionnaires. Symptoms of depression and anxiety, aggressive behavior, and Attention-Deficit/Hyperactivity Disorder (ADHD) in children were assessed using mother-reported tests and classified within the normal or borderline/clinical ranges using validated cut-offs. Adjusted odds ratios were determined by multivariable logistic regression models and aggregated by the two-level individual participant data meta-analysis method.

Results
Higher maternal DASH scores (indicating better dietary quality) were associated with lower risk of depressive and anxiety symptoms, aggressive behavior symptoms and ADHD symptoms within the borderline/clinical ranges (OR (95%CI): 0.97 (0.95, 0.99), 0.97 (0.94, 0.99), 0.97 (0.95, 0.98) per one-unit DASH score increase, respectively). A one-unit increase in E-DII scores (more pro-inflammatory diet) was associated with a 7% increased risk of all three analyzed emotional and behavioral symptoms (OR (95%CI): 1.07 (1.03, 1.11), 1.07 (1.02, 1.13), 1.07 (1.01, 1.13) for depression and anxiety, aggressive behavior, and ADHD symptoms, respectively).

Conclusions
Our findings suggest that maternal low-quality and pro-inflammatory diet may increase risk of emotional and behavioral symptoms in children.

Original language	English
Article number	10
Pages (from-to)	550-559
Number of pages	10
Journal	Biological Psychiatry
Volume	89
Issue number	6
Early online date	24 Oct 2020
DOIs	https://doi.org/10.1016/j.biopsych.2020.10.008
Publication status	Published - 15 Mar 2021

Keywords

pregnancy
Dietary Approaches to Stop Hypertension
energy-adjusted Dietary
Inflammatory Index
depressive and anxiety symptoms
aggressive behavior symptoms
Attention-Deficit/Hyperactivity Disorder symptoms

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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IEU 2 Relton Programme - Epigenetic Epidemiology
Relton, C. L.
1/04/18 → 31/03/23
Project: Research
Rework of Early life programming of childhood health: a nutritional and epigenetic investigation of adiposity and bone, cardiometabolic, neurodevelopmental and respiratory health
Relton, C. L.
1/04/17 → 31/05/20
Project: Research

Cite this

Polanska, K., Kalunzy, P., Aubert, A. M., Bernard, J. Y., Duijts, L., El Marrroun, H., Hanke, W., Hébert, J. R., Heude, B., Jankowska, A., Mancano, G., Mensink-Bout, S. M., Relton, C. L., Shivappa, N., Suderman, M. J., Trafalska, E., Wesoloska, E., Garcia-Esteban, R., & Phillips, C. M. (2021). Dietary quality and dietary inflammatory potential during pregnancy and offspring emotional and behavioral symptoms in childhood: an individual participant data metaanalysis of four European cohorts. Biological Psychiatry, 89(6), 550-559. Article 10. https://doi.org/10.1016/j.biopsych.2020.10.008

@article{a324e926df5b433283164e7f19afadf6,

title = "Dietary quality and dietary inflammatory potential during pregnancy and offspring emotional and behavioral symptoms in childhood: an individual participant data metaanalysis of four European cohorts",

abstract = "BackgroundThe impact of maternal diet during pregnancy on child neurodevelopment is of public health and clinical relevance. We evaluated associations of dietary quality (based on Dietary Approaches to Stop Hypertension (DASH) score) and dietary inflammatory potential (based on energy-adjusted Dietary Inflammatory Index (E-DII) score) during pregnancy with offspring emotional and behavioral symptoms at 7-10 years of age.MethodsIndividual participant data for 11,870 mother-child pairs from four European cohorts participating in ALPHABET project were analyzed. Maternal antenatal DASH and E-DII scores were generated from self-completed food frequency questionnaires. Symptoms of depression and anxiety, aggressive behavior, and Attention-Deficit/Hyperactivity Disorder (ADHD) in children were assessed using mother-reported tests and classified within the normal or borderline/clinical ranges using validated cut-offs. Adjusted odds ratios were determined by multivariable logistic regression models and aggregated by the two-level individual participant data meta-analysis method.ResultsHigher maternal DASH scores (indicating better dietary quality) were associated with lower risk of depressive and anxiety symptoms, aggressive behavior symptoms and ADHD symptoms within the borderline/clinical ranges (OR (95%CI): 0.97 (0.95, 0.99), 0.97 (0.94, 0.99), 0.97 (0.95, 0.98) per one-unit DASH score increase, respectively). A one-unit increase in E-DII scores (more pro-inflammatory diet) was associated with a 7% increased risk of all three analyzed emotional and behavioral symptoms (OR (95%CI): 1.07 (1.03, 1.11), 1.07 (1.02, 1.13), 1.07 (1.01, 1.13) for depression and anxiety, aggressive behavior, and ADHD symptoms, respectively).ConclusionsOur findings suggest that maternal low-quality and pro-inflammatory diet may increase risk of emotional and behavioral symptoms in children.",

keywords = "pregnancy, Dietary Approaches to Stop Hypertension, energy-adjusted Dietary, Inflammatory Index, depressive and anxiety symptoms, aggressive behavior symptoms, Attention-Deficit/Hyperactivity Disorder symptoms",

author = "Kinga Polanska and Pawel Kalunzy and Aubert, {Adrien M} and Bernard, {Jonathan Y} and Liesbeth Duijts and {El Marrroun}, Hanan and Wojciech Hanke and H{\'e}bert, {James R} and Barbara Heude and A Jankowska and Giulia Mancano and Mensink-Bout, {Sara M} and Relton, {Caroline L} and Nitin Shivappa and Suderman, {Matthew J} and E Trafalska and Ewelina Wesoloska and R Garcia-Esteban and Phillips, {Catherine M}",

year = "2021",

month = mar,

day = "15",

doi = "10.1016/j.biopsych.2020.10.008",

language = "English",

volume = "89",

pages = "550--559",

journal = "Biological Psychiatry",

issn = "0006-3223",

publisher = "Elsevier Inc.",

number = "6",

}

Polanska, K, Kalunzy, P, Aubert, AM, Bernard, JY, Duijts, L, El Marrroun, H, Hanke, W, Hébert, JR, Heude, B, Jankowska, A, Mancano, G, Mensink-Bout, SM, Relton, CL, Shivappa, N, Suderman, MJ, Trafalska, E, Wesoloska, E, Garcia-Esteban, R & Phillips, CM 2021, 'Dietary quality and dietary inflammatory potential during pregnancy and offspring emotional and behavioral symptoms in childhood: an individual participant data metaanalysis of four European cohorts', Biological Psychiatry, vol. 89, no. 6, 10, pp. 550-559. https://doi.org/10.1016/j.biopsych.2020.10.008

Dietary quality and dietary inflammatory potential during pregnancy and offspring emotional and behavioral symptoms in childhood: an individual participant data metaanalysis of four European cohorts. / Polanska, Kinga; Kalunzy, Pawel; Aubert, Adrien M et al.
In: Biological Psychiatry, Vol. 89, No. 6, 10, 15.03.2021, p. 550-559.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

TY - JOUR

T1 - Dietary quality and dietary inflammatory potential during pregnancy and offspring emotional and behavioral symptoms in childhood

T2 - an individual participant data metaanalysis of four European cohorts

AU - Polanska, Kinga

AU - Kalunzy, Pawel

AU - Aubert, Adrien M

AU - Bernard, Jonathan Y

AU - Duijts, Liesbeth

AU - El Marrroun, Hanan

AU - Hanke, Wojciech

AU - Hébert, James R

AU - Heude, Barbara

AU - Jankowska, A

AU - Mancano, Giulia

AU - Mensink-Bout, Sara M

AU - Relton, Caroline L

AU - Shivappa, Nitin

AU - Suderman, Matthew J

AU - Trafalska, E

AU - Wesoloska, Ewelina

AU - Garcia-Esteban, R

AU - Phillips, Catherine M

PY - 2021/3/15

Y1 - 2021/3/15

N2 - BackgroundThe impact of maternal diet during pregnancy on child neurodevelopment is of public health and clinical relevance. We evaluated associations of dietary quality (based on Dietary Approaches to Stop Hypertension (DASH) score) and dietary inflammatory potential (based on energy-adjusted Dietary Inflammatory Index (E-DII) score) during pregnancy with offspring emotional and behavioral symptoms at 7-10 years of age.MethodsIndividual participant data for 11,870 mother-child pairs from four European cohorts participating in ALPHABET project were analyzed. Maternal antenatal DASH and E-DII scores were generated from self-completed food frequency questionnaires. Symptoms of depression and anxiety, aggressive behavior, and Attention-Deficit/Hyperactivity Disorder (ADHD) in children were assessed using mother-reported tests and classified within the normal or borderline/clinical ranges using validated cut-offs. Adjusted odds ratios were determined by multivariable logistic regression models and aggregated by the two-level individual participant data meta-analysis method.ResultsHigher maternal DASH scores (indicating better dietary quality) were associated with lower risk of depressive and anxiety symptoms, aggressive behavior symptoms and ADHD symptoms within the borderline/clinical ranges (OR (95%CI): 0.97 (0.95, 0.99), 0.97 (0.94, 0.99), 0.97 (0.95, 0.98) per one-unit DASH score increase, respectively). A one-unit increase in E-DII scores (more pro-inflammatory diet) was associated with a 7% increased risk of all three analyzed emotional and behavioral symptoms (OR (95%CI): 1.07 (1.03, 1.11), 1.07 (1.02, 1.13), 1.07 (1.01, 1.13) for depression and anxiety, aggressive behavior, and ADHD symptoms, respectively).ConclusionsOur findings suggest that maternal low-quality and pro-inflammatory diet may increase risk of emotional and behavioral symptoms in children.

AB - BackgroundThe impact of maternal diet during pregnancy on child neurodevelopment is of public health and clinical relevance. We evaluated associations of dietary quality (based on Dietary Approaches to Stop Hypertension (DASH) score) and dietary inflammatory potential (based on energy-adjusted Dietary Inflammatory Index (E-DII) score) during pregnancy with offspring emotional and behavioral symptoms at 7-10 years of age.MethodsIndividual participant data for 11,870 mother-child pairs from four European cohorts participating in ALPHABET project were analyzed. Maternal antenatal DASH and E-DII scores were generated from self-completed food frequency questionnaires. Symptoms of depression and anxiety, aggressive behavior, and Attention-Deficit/Hyperactivity Disorder (ADHD) in children were assessed using mother-reported tests and classified within the normal or borderline/clinical ranges using validated cut-offs. Adjusted odds ratios were determined by multivariable logistic regression models and aggregated by the two-level individual participant data meta-analysis method.ResultsHigher maternal DASH scores (indicating better dietary quality) were associated with lower risk of depressive and anxiety symptoms, aggressive behavior symptoms and ADHD symptoms within the borderline/clinical ranges (OR (95%CI): 0.97 (0.95, 0.99), 0.97 (0.94, 0.99), 0.97 (0.95, 0.98) per one-unit DASH score increase, respectively). A one-unit increase in E-DII scores (more pro-inflammatory diet) was associated with a 7% increased risk of all three analyzed emotional and behavioral symptoms (OR (95%CI): 1.07 (1.03, 1.11), 1.07 (1.02, 1.13), 1.07 (1.01, 1.13) for depression and anxiety, aggressive behavior, and ADHD symptoms, respectively).ConclusionsOur findings suggest that maternal low-quality and pro-inflammatory diet may increase risk of emotional and behavioral symptoms in children.

KW - pregnancy

KW - Dietary Approaches to Stop Hypertension

KW - energy-adjusted Dietary

KW - Inflammatory Index

KW - depressive and anxiety symptoms

KW - aggressive behavior symptoms

KW - Attention-Deficit/Hyperactivity Disorder symptoms

U2 - 10.1016/j.biopsych.2020.10.008

DO - 10.1016/j.biopsych.2020.10.008

M3 - Article (Academic Journal)

C2 - 33358009

SN - 0006-3223

VL - 89

SP - 550

EP - 559

JO - Biological Psychiatry

JF - Biological Psychiatry

IS - 6

M1 - 10

ER -

Polanska K, Kalunzy P, Aubert AM, Bernard JY, Duijts L, El Marrroun H et al. Dietary quality and dietary inflammatory potential during pregnancy and offspring emotional and behavioral symptoms in childhood: an individual participant data metaanalysis of four European cohorts. Biological Psychiatry. 2021 Mar 15;89(6):550-559. 10. Epub 2020 Oct 24. doi: 10.1016/j.biopsych.2020.10.008

Dietary quality and dietary inflammatory potential during pregnancy and offspring emotional and behavioral symptoms in childhood: an individual participant data metaanalysis of four European cohorts

Abstract

Keywords

UN SDGs

Access to Document

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Projects

IEU 2 Relton Programme - Epigenetic Epidemiology

Rework of Early life programming of childhood health: a nutritional and epigenetic investigation of adiposity and bone, cardiometabolic, neurodevelopmental and respiratory health

Cite this