Differences in smoking associated DNA methylation patterns in South Asians and Europeans

Hannah R. Elliott, Therese Tillin, Wendy L. McArdle, Karen Ho, Aparna Duggirala, Tim M. Frayling, George Davey Smith, Alun D. Hughes, Nish Chaturvedi, Caroline L. Relton

Research output: Contribution to journalArticle (Academic Journal)peer-review

137 Citations (Scopus)

Abstract

DNA methylation is strongly associated with smoking status at multiple sites across the genome. Studies have largely been restricted to European origin individuals yet the greatest increase in smoking is occurring in low income countries, such as the Indian subcontinent. We determined whether there are differences between South Asians and Europeans in smoking related loci, and if a smoking score, combining all smoking related DNA methylation scores, could differentiate smokers from non-smokers.
Original languageEnglish
Pages (from-to)4
JournalClinical Epigenetics
Volume6
Issue number1
DOIs
Publication statusPublished - 3 Feb 2014

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