Differential Associations of Inflammatory Markers With Insulin Sensitivity and Secretion: The Prospective METSIM Study

Maria Fizelova, Raimo Jauhiainen, Antti J Kangas, Pasi Soininen, Mika Ala-Korpela, Johanna Kuusisto, Markku Laakso, Alena Stancáková

Research output: Contribution to journalArticle (Academic Journal)peer-review

22 Citations (Scopus)
181 Downloads (Pure)


Context: Low-grade inflammation is involved in the development of type 2 diabetes and cardiovascular disease (CVD); however, prospective studies evaluating inflammatory markers as predictors of changes in insulin secretion and insulin sensitivity are lacking.

Objective: We investigated the associations of glycoprotein acetyls (GlycA), interleukin-1 receptor antagonist (IL-1RA), and high-sensitivity C-reactive protein (hs-CRP) with insulin secretion, insulin sensitivity, incident type 2 diabetes, hypertension, CVD events, and total mortality in the prospective Metabolic Syndrome in Men (METSIM) study.

Design: A prospective study.

Participants: The cross-sectional METSIM study included 8749 nondiabetic Finnish men aged 45 to 73 years, who had been randomly selected from the population register of Kuopio, Finland. A total of 5401 men participated in the 6.8-year follow-up study.

Main Outcome Measures: Changes in insulin secretion, insulin sensitivity, and cardiometabolic traits during the follow-up period and the incidence of type 2 diabetes, hypertension, CVD events, and total mortality.

Results: During the follow-up period, GlycA was associated with impaired insulin secretion, hyperglycemia, incident type 2 diabetes (hazard ratio, 1.37; 95% confidence interval, 1.29 to 1.46) and CVD (hazard ratio, 1.21; 95% confidence interval, 1.12 to 1.32). IL-1RA and hs-CRP were associated with adverse changes in insulin sensitivity and obesity-related traits and with total mortality (hazard ratio, 1.13; 95% confidence interval, 1.07 to 1.20; and hazard ratio, 1.08; 95% confidence interval, 1.04 to 1.11, respectively).

Conclusions: Inflammatory markers differentially predicted changes in insulin secretion and insulin sensitivity. GlycA predicted impaired insulin secretion, and IL-1RA and hs-CRP predicted changes in insulin sensitivity. Combining the three markers improved the prediction of disease outcomes, suggesting that they capture different aspects of low-grade inflammation.

Original languageEnglish
Pages (from-to)3600-3609
Number of pages10
JournalJournal of Clinical Endocrinology and Metabolism
Issue number9
Early online date20 Jul 2017
Publication statusPublished - 1 Sep 2017


  • Age Factors
  • Aged
  • Biomarkers/blood
  • C-Reactive Protein/metabolism
  • Cardiovascular Diseases/epidemiology
  • Cross-Sectional Studies
  • Diabetes Mellitus, Type 2/epidemiology
  • Disease Progression
  • Finland/epidemiology
  • Glycoproteins/metabolism
  • Humans
  • Hypertension/epidemiology
  • Incidence
  • Insulin Resistance
  • Male
  • Metabolic Syndrome/epidemiology
  • Middle Aged
  • Prognosis
  • Prospective Studies
  • Risk Assessment
  • Survival Analysis

Fingerprint Dive into the research topics of 'Differential Associations of Inflammatory Markers With Insulin Sensitivity and Secretion: The Prospective METSIM Study'. Together they form a unique fingerprint.

Cite this