Differential mood response to natural and synthetic corticosteroids after bilateral adrenalectomy: a case report

E Seifritz, U Hemmeter, W Pöldinger, E R Froesch, J M Reul, E Holsboer-Trachsler

Research output: Contribution to journalArticle (Academic Journal)peer-review

7 Citations (Scopus)

Abstract

A 48-year-old woman who had had a bilateral adrenalectomy for Cushing's syndrome developed severe psychotic symptoms that were unresponsive to psychotropic drugs as long as she was taking prednisone (PRED) as replacement therapy. However, after she was switched to a regimen of cortisol (CORT) and fludrocortone (FLUD) the psychopathology disappeared. Mechanisms related to the differences in the interaction of natural (e.g. CORT) and synthetic (e.g. PRED) corticosteroids with the central glucocorticoid and mineralocorticoid receptors may explain the different effects upon psychopathology.

Original languageEnglish
Pages (from-to)7-11
Number of pages5
JournalJournal of Psychiatric Research
Volume28
Issue number1
Publication statusPublished - 1 Jan 1994

Keywords

  • Adrenalectomy
  • Affect
  • Cushing Syndrome
  • Delirium, Dementia, Amnestic, Cognitive Disorders
  • Drug Therapy, Combination
  • Female
  • Fludrocortisone
  • Humans
  • Hydrocortisone
  • Hypothalamo-Hypophyseal System
  • Middle Aged
  • Pituitary-Adrenal System
  • Postoperative Complications
  • Prednisone
  • Receptors, Glucocorticoid
  • Receptors, Mineralocorticoid

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