Differential mood response to natural and synthetic corticosteroids after bilateral adrenalectomy: a case report

E Seifritz; U Hemmeter; W Pöldinger; E R Froesch; J M Reul; E Holsboer-Trachsler

Differential mood response to natural and synthetic corticosteroids after bilateral adrenalectomy: a case report

E Seifritz, U Hemmeter, W Pöldinger, E R Froesch, J M Reul, E Holsboer-Trachsler

Research output: Contribution to journal › Article (Academic Journal) › peer-review

7 Citations (Scopus)

Abstract

A 48-year-old woman who had had a bilateral adrenalectomy for Cushing's syndrome developed severe psychotic symptoms that were unresponsive to psychotropic drugs as long as she was taking prednisone (PRED) as replacement therapy. However, after she was switched to a regimen of cortisol (CORT) and fludrocortone (FLUD) the psychopathology disappeared. Mechanisms related to the differences in the interaction of natural (e.g. CORT) and synthetic (e.g. PRED) corticosteroids with the central glucocorticoid and mineralocorticoid receptors may explain the different effects upon psychopathology.

Original language	English
Pages (from-to)	7-11
Number of pages	5
Journal	Journal of Psychiatric Research
Volume	28
Issue number	1
Publication status	Published - 1 Jan 1994

Keywords

Adrenalectomy
Affect
Cushing Syndrome
Delirium, Dementia, Amnestic, Cognitive Disorders
Drug Therapy, Combination
Female
Fludrocortisone
Humans
Hydrocortisone
Hypothalamo-Hypophyseal System
Middle Aged
Pituitary-Adrenal System
Postoperative Complications
Prednisone
Receptors, Glucocorticoid
Receptors, Mineralocorticoid

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title = "Differential mood response to natural and synthetic corticosteroids after bilateral adrenalectomy: a case report",

abstract = "A 48-year-old woman who had had a bilateral adrenalectomy for Cushing's syndrome developed severe psychotic symptoms that were unresponsive to psychotropic drugs as long as she was taking prednisone (PRED) as replacement therapy. However, after she was switched to a regimen of cortisol (CORT) and fludrocortone (FLUD) the psychopathology disappeared. Mechanisms related to the differences in the interaction of natural (e.g. CORT) and synthetic (e.g. PRED) corticosteroids with the central glucocorticoid and mineralocorticoid receptors may explain the different effects upon psychopathology.",

keywords = "Adrenalectomy, Affect, Cushing Syndrome, Delirium, Dementia, Amnestic, Cognitive Disorders, Drug Therapy, Combination, Female, Fludrocortisone, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Middle Aged, Pituitary-Adrenal System, Postoperative Complications, Prednisone, Receptors, Glucocorticoid, Receptors, Mineralocorticoid",

author = "E Seifritz and U Hemmeter and W P{\"o}ldinger and Froesch, {E R} and Reul, {J M} and E Holsboer-Trachsler",

year = "1994",

month = jan,

day = "1",

language = "English",

volume = "28",

pages = "7--11",

journal = "Journal of Psychiatric Research",

issn = "0022-3956",

publisher = "Elsevier Limited",

number = "1",

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TY - JOUR

T1 - Differential mood response to natural and synthetic corticosteroids after bilateral adrenalectomy: a case report

AU - Seifritz, E

AU - Hemmeter, U

AU - Pöldinger, W

AU - Froesch, E R

AU - Reul, J M

AU - Holsboer-Trachsler, E

PY - 1994/1/1

Y1 - 1994/1/1

N2 - A 48-year-old woman who had had a bilateral adrenalectomy for Cushing's syndrome developed severe psychotic symptoms that were unresponsive to psychotropic drugs as long as she was taking prednisone (PRED) as replacement therapy. However, after she was switched to a regimen of cortisol (CORT) and fludrocortone (FLUD) the psychopathology disappeared. Mechanisms related to the differences in the interaction of natural (e.g. CORT) and synthetic (e.g. PRED) corticosteroids with the central glucocorticoid and mineralocorticoid receptors may explain the different effects upon psychopathology.

AB - A 48-year-old woman who had had a bilateral adrenalectomy for Cushing's syndrome developed severe psychotic symptoms that were unresponsive to psychotropic drugs as long as she was taking prednisone (PRED) as replacement therapy. However, after she was switched to a regimen of cortisol (CORT) and fludrocortone (FLUD) the psychopathology disappeared. Mechanisms related to the differences in the interaction of natural (e.g. CORT) and synthetic (e.g. PRED) corticosteroids with the central glucocorticoid and mineralocorticoid receptors may explain the different effects upon psychopathology.

KW - Adrenalectomy

KW - Affect

KW - Cushing Syndrome

KW - Delirium, Dementia, Amnestic, Cognitive Disorders

KW - Drug Therapy, Combination

KW - Female

KW - Fludrocortisone

KW - Humans

KW - Hydrocortisone

KW - Hypothalamo-Hypophyseal System

KW - Middle Aged

KW - Pituitary-Adrenal System

KW - Postoperative Complications

KW - Prednisone

KW - Receptors, Glucocorticoid

KW - Receptors, Mineralocorticoid

M3 - Article (Academic Journal)

C2 - 8064642

VL - 28

SP - 7

EP - 11

JO - Journal of Psychiatric Research

JF - Journal of Psychiatric Research

SN - 0022-3956

IS - 1

ER -