Differential regulation of L1 and L2 β-lactamase expression in Stenotrophomonas maltophilia

MB Avison, CS Higgins, PJ Ford, CJ von Heldreich, TR Walsh, PM Bennett

Research output: Contribution to journalArticle (Academic Journal)peer-review

Abstract

It has been reported that Stenotrophomonas maltophilia L1 and L2 beta-lactamase expression is coordinated. We have isolated S. maltophilia mutants where (i) L1 is constitutively hyper-expressed and L2 is inducible; (ii) L2 is hyper-expressed and L1 is inducible; and (iii) L1 and L2 are constitutively hyper-expressed. The frequency of isolating type 1 and 2 mutants is c. 10(-7), indicating that promoter mutations are probably not involved and providing strong evidence that L1 and L2 expression is not, after all, coordinated. The frequency of isolating type 3 mutants is c. 10(-9), however, implying that there is a significant overlap between the regulatory mechanisms.
Translated title of the contributionDifferential regulation of L1 and L2 β-lactamase expression in Stenotrophomonas maltophilia
Original languageEnglish
Pages (from-to)387 - 389
Number of pages3
JournalJournal of Antimicrobial Chemotherapy
Volume49
Publication statusPublished - Feb 2002

Bibliographical note

Publisher: Oxford University Press
Other: Authors Ford & von Heldreich were UG students

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