Differential responses of rabbit ventricular and atrial transient outward current (Ito) to the Ito modulator NS5806

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  INVESTIGATION OF CARDIAC LATE SODIUM CURRENT AS A THERAPEUTIC TARGET IN RETT SYNDROME

  Hancox, J. C. (Principal Investigator)

  1/10/16 → 30/09/19

  Project: Research

  • Action Potential 100%
  • Rett Syndrome 73%
  • Action Potential Duration 40%
  • IC50 40%
  • Muscle Cell 40%

• Revised: Relationship between early and late events in the cardiac cycle as control points of pharmacological intervention

  Cannell, M. B. (Principal Investigator)

  1/02/16 → 31/01/21

  Project: Research

  • Leporidae 100%
  • Cardiac Muscle Cell 77%
  • Action Potential 72%
  • Calcium Ion 66%
  • Muscle Cell 58%

• IP3 receptor modulation of the atrioventricular node

  Hancox, J. C. (Principal Investigator)

  1/10/14 → 1/10/16

  Project: Research

  • Leporidae 100%
  • Muscle Cell 44%
  • Sodium Ion 42%
  • Sodium Current 28%
  • Action Potential 26%