Projects per year
Abstract
Galanin is expressed in a small percentage of intact small diameter sensory neurons of the dorsal root ganglia and in the afferent terminals of the superficial lamina of the dorsal horn of the spinal cord. The neuropeptide modulates nociception demonstrating dose-dependent pro- and anti-nociceptive actions in the naïve animal. Galanin also plays an important role in chronic pain, with the anti-nociceptive actions enhanced in rodent neuropathic pain models. In this study we compared the role played by galanin and its receptors in mechanical and cold allodynia by identifying individual rat C-fibre nociceptors and characterising their responses to mechanical or acetone stimulation.
Original language | English |
---|---|
Pages (from-to) | 41 |
Journal | Molecular Pain |
Volume | 8 |
DOIs | |
Publication status | Published - 2012 |
Fingerprint
Dive into the research topics of 'Differential roles of galanin on mechanical and cooling responses at the primary afferent nociceptor'. Together they form a unique fingerprint.Projects
- 2 Finished
-
THE ROLE OF GALANIN IN THE ADAPTIVE RESPONSE OF THE PERIPHERAL NERVOUS SYSTEMT O INJURY
Wynick, D. (Principal Investigator)
1/08/03 → 1/08/08
Project: Research
-
PERIODONTAL DISEASE AND THE RELATIONSHIP BETWEEN INFLAMMATION AND PAIN
Donaldson, L. F. (Principal Investigator)
1/05/01 → 1/11/06
Project: Research