Differential roles of galanin on mechanical and cooling responses at the primary afferent nociceptor

Richard P Hulse; Lucy F Donaldson; David Wynick

doi:10.1186/1744-8069-8-41

Differential roles of galanin on mechanical and cooling responses at the primary afferent nociceptor

Richard P Hulse, Lucy F Donaldson, David Wynick

Research output: Contribution to journal › Article (Academic Journal)

11 Citations (Scopus)

Abstract

Galanin is expressed in a small percentage of intact small diameter sensory neurons of the dorsal root ganglia and in the afferent terminals of the superficial lamina of the dorsal horn of the spinal cord. The neuropeptide modulates nociception demonstrating dose-dependent pro- and anti-nociceptive actions in the naïve animal. Galanin also plays an important role in chronic pain, with the anti-nociceptive actions enhanced in rodent neuropathic pain models. In this study we compared the role played by galanin and its receptors in mechanical and cold allodynia by identifying individual rat C-fibre nociceptors and characterising their responses to mechanical or acetone stimulation.

Original language	English
Pages (from-to)	41
Journal	Molecular Pain
Volume	8
DOIs	https://doi.org/10.1186/1744-8069-8-41
Publication status	Published - 2012

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10.1186/1744-8069-8-41

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Projects

2 Finished

THE ROLE OF GALANIN IN THE ADAPTIVE RESPONSE OF THE PERIPHERAL NERVOUS SYSTEMT O INJURY

Wynick, D.

1/08/03 → 1/08/08

Project: Research

PERIODONTAL DISEASE AND THE RELATIONSHIP BETWEEN INFLAMMATION AND PAIN

Donaldson, L. F.

1/05/01 → 1/11/06

Project: Research

Cite this

Hulse, R. P., Donaldson, L. F., & Wynick, D. (2012). Differential roles of galanin on mechanical and cooling responses at the primary afferent nociceptor. Molecular Pain, 8, 41. https://doi.org/10.1186/1744-8069-8-41

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