Differential roles of galanin on mechanical and cooling responses at the primary afferent nociceptor

Richard P Hulse, Lucy F Donaldson, David Wynick

Research output: Contribution to journalArticle (Academic Journal)

11 Citations (Scopus)

Abstract

Galanin is expressed in a small percentage of intact small diameter sensory neurons of the dorsal root ganglia and in the afferent terminals of the superficial lamina of the dorsal horn of the spinal cord. The neuropeptide modulates nociception demonstrating dose-dependent pro- and anti-nociceptive actions in the naïve animal. Galanin also plays an important role in chronic pain, with the anti-nociceptive actions enhanced in rodent neuropathic pain models. In this study we compared the role played by galanin and its receptors in mechanical and cold allodynia by identifying individual rat C-fibre nociceptors and characterising their responses to mechanical or acetone stimulation.
Original languageEnglish
Pages (from-to)41
JournalMolecular Pain
Volume8
DOIs
Publication statusPublished - 2012

Fingerprint Dive into the research topics of 'Differential roles of galanin on mechanical and cooling responses at the primary afferent nociceptor'. Together they form a unique fingerprint.

  • Projects

    Cite this