Direct and indirect resource use, healthcare costs and work force absence in patients with non-infectious intermediate, posterior or panuveitis

Jennifer E Thorne, Martha Skup, Namita Tundia, Dendy Macaulay, Cindy Revol, Jingdong Chao, Avani Joshi, Andrew D Dick

Research output: Contribution to journalArticle (Academic Journal)peer-review

31 Citations (Scopus)
294 Downloads (Pure)

Abstract

PURPOSE: To ascertain resource use, costs and risk of workforce absence in non-infectious uveitis cases versus matched controls.

METHODS: In a retrospective claims analysis of employees in the United States, prevalent (N = 705) and incident (N = 776) cases 18-64 years old with ≥2 diagnoses of non-infectious intermediate, posterior or panuveitis were matched 1:1 to controls without uveitis. Persistent prevalent cases (treated for ≥90 days, N = 112) also were analysed. Outcomes were annual direct resource use and costs associated with inpatient stays; emergency department, outpatient and ophthalmologist/optometrist visits; and prescription drugs. Indirect resource use and costs associated with work loss from disability and medically related absenteeism also were compared. Multivariate regression assessed cost differences between cases and controls.

RESULTS: Cases had significantly (p < 0.05) more medical resource use versus controls including 0.4 versus 0.2 emergency visits and 16.5 versus 7.6 outpatient/other visits. Cases used more prescription drugs (7.8 versus 4.1) and had more disability days (10.3 versus 4.6), medically related absenteeism days (8.5 versus 3.8), and work loss days (18.7 versus 8.4) than controls (all p < 0.05). Total direct ($12 940 versus $3730) and indirect ($3144 versus $1378) costs were higher in cases than controls (all p < 0.05). Results for persistent cases suggested greater utilization and associated cost and work loss burden. Compared with controls, cases had significantly greater risks of workforce absence, leave of absence and long-term disability (all p < 0.05).

CONCLUSION: Non-infectious intermediate, posterior or panuveitis, particularly persistent disease, is associated with substantial medical and work loss costs suggesting an unmet need for more effective treatments.

Original languageEnglish
Pages (from-to)e331-e339
Number of pages9
JournalActa Ophthalmologica
Volume94
Issue number5
Early online date2 Mar 2016
DOIs
Publication statusPublished - Aug 2016

Keywords

  • direct costs; indirect costs; non-infectious; persistent; uveitis; work disability

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