Direct and Regioselective C-H Alkenylation of Tetrahydropyrido[1,2-a]pyrimidines

D Cheng, T Gallagher

Research output: Contribution to journalArticle (Academic Journal)peer-review

66 Citations (Scopus)

Abstract

The electrophilic C-H palladation and Heck-type alkenylation of the tetrahydro[1,2-a]pyrimidine scaffold leads to exclusive formation of the C(7) adducts and this palladium-catalyzed process is applicable to a broad range of alkenyl components. Mechanistic studies suggest that palladation is selective for C(7) and there was no evidence for C(9) metallation; the latter corresponds to the pathway observed previously with N-methylpyridone.
Translated title of the contributionDirect and Regioselective C-H Alkenylation of Tetrahydropyrido[1,2-a]pyrimidines
Original languageEnglish
Pages (from-to)2639 - 2641
Number of pages3
JournalOrganic Letters
Volume11
Issue number12
DOIs
Publication statusPublished - May 2009

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