The electrophilic C-H palladation and Heck-type alkenylation of the tetrahydro[1,2-a]pyrimidine scaffold leads to exclusive formation of the C(7) adducts and this palladium-catalyzed process is applicable to a broad range of alkenyl components. Mechanistic studies suggest that palladation is selective for C(7) and there was no evidence for C(9) metallation; the latter corresponds to the pathway observed previously with N-methylpyridone.
|Translated title of the contribution||Direct and Regioselective C-H Alkenylation of Tetrahydropyrido[1,2-a]pyrimidines|
|Pages (from-to)||2639 - 2641|
|Number of pages||3|
|Publication status||Published - May 2009|