Discovery and refinement of loci associated with lipid levels

Cristen J Willer; Ellen M Schmidt; Sebanti Sengupta; Gina M Peloso; Stefan Gustafsson; Stavroula Kanoni; Andrea Ganna; Jin Chen; Martin L Buchkovich; Samia Mora; Jacques S Beckmann; Jennifer L Bragg-Gresham; Hsing-Yi Chang; Ayşe Demirkan; Heleen M Den Hertog; Ron Do; Louise A Donnelly; Georg B Ehret; Tõnu Esko; Mary F Feitosa; Teresa Ferreira; Krista Fischer; Pierre Fontanillas; Ross M Fraser; Daniel F Freitag; Deepti Gurdasani; Kauko Heikkilä; Elina Hyppönen; Aaron Isaacs; Anne U Jackson; Asa Johansson; Toby Johnson; Marika Kaakinen; Johannes Kettunen; Marcus E Kleber; Xiaohui Li; Jian'an Luan; Leo-Pekka Lyytikäinen; Patrik K E Magnusson; Massimo Mangino; Evelin Mihailov; May E Montasser; Martina Müller-Nurasyid; Ilja M Nolte; Jeffrey R O'Connell; Cameron D Palmer; Markus Perola; Dmitry Shungin; Wendy L McArdle; Mika Kivimaki; Global Lipids Genetics Consortium

doi:10.1038/ng.2797

Discovery and refinement of loci associated with lipid levels

Cristen J Willer, Ellen M Schmidt, Sebanti Sengupta, Gina M Peloso, Stefan Gustafsson, Stavroula Kanoni, Andrea Ganna, Jin Chen, Martin L Buchkovich, Samia Mora, Jacques S Beckmann, Jennifer L Bragg-Gresham, Hsing-Yi Chang, Ayşe Demirkan, Heleen M Den Hertog, Ron Do, Louise A Donnelly, Georg B Ehret, Tõnu Esko, Mary F FeitosaTeresa Ferreira, Krista Fischer, Pierre Fontanillas, Ross M Fraser, Daniel F Freitag, Deepti Gurdasani, Kauko Heikkilä, Elina Hyppönen, Aaron Isaacs, Anne U Jackson, Asa Johansson, Toby Johnson, Marika Kaakinen, Johannes Kettunen, Marcus E Kleber, Xiaohui Li, Jian'an Luan, Leo-Pekka Lyytikäinen, Patrik K E Magnusson, Massimo Mangino, Evelin Mihailov, May E Montasser, Martina Müller-Nurasyid, Ilja M Nolte, Jeffrey R O'Connell, Cameron D Palmer, Markus Perola, Dmitry Shungin, Wendy L McArdle, Mika Kivimaki, Global Lipids Genetics Consortium

Bristol Medical School (PHS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

2232 Citations (Scopus)

Abstract

Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P

Original language	English
Journal	Nature Genetics
DOIs	https://doi.org/10.1038/ng.2797
Publication status	Published - 6 Oct 2013

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Willer, C. J., Schmidt, E. M., Sengupta, S., Peloso, G. M., Gustafsson, S., Kanoni, S., Ganna, A., Chen, J., Buchkovich, M. L., Mora, S., Beckmann, J. S., Bragg-Gresham, J. L., Chang, H.-Y., Demirkan, A., Den Hertog, H. M., Do, R., Donnelly, L. A., Ehret, G. B., Esko, T., ... Global Lipids Genetics Consortium (2013). Discovery and refinement of loci associated with lipid levels. Nature Genetics. https://doi.org/10.1038/ng.2797

@article{a2dbb793b99e4076bdda01fe16d9c7b3,

title = "Discovery and refinement of loci associated with lipid levels",

abstract = "Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P ",

author = "Willer, {Cristen J} and Schmidt, {Ellen M} and Sebanti Sengupta and Peloso, {Gina M} and Stefan Gustafsson and Stavroula Kanoni and Andrea Ganna and Jin Chen and Buchkovich, {Martin L} and Samia Mora and Beckmann, {Jacques S} and Bragg-Gresham, {Jennifer L} and Hsing-Yi Chang and Ay{\c s}e Demirkan and {Den Hertog}, {Heleen M} and Ron Do and Donnelly, {Louise A} and Ehret, {Georg B} and T{\~o}nu Esko and Feitosa, {Mary F} and Teresa Ferreira and Krista Fischer and Pierre Fontanillas and Fraser, {Ross M} and Freitag, {Daniel F} and Deepti Gurdasani and Kauko Heikkil{\"a} and Elina Hypp{\"o}nen and Aaron Isaacs and Jackson, {Anne U} and Asa Johansson and Toby Johnson and Marika Kaakinen and Johannes Kettunen and Kleber, {Marcus E} and Xiaohui Li and Jian'an Luan and Leo-Pekka Lyytik{\"a}inen and Magnusson, {Patrik K E} and Massimo Mangino and Evelin Mihailov and Montasser, {May E} and Martina M{\"u}ller-Nurasyid and Nolte, {Ilja M} and O'Connell, {Jeffrey R} and Palmer, {Cameron D} and Markus Perola and Dmitry Shungin and McArdle, {Wendy L} and Mika Kivimaki and {Global Lipids Genetics Consortium}",

year = "2013",

month = oct,

day = "6",

doi = "10.1038/ng.2797",

language = "English",

journal = "Nature Genetics",

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Willer, CJ, Schmidt, EM, Sengupta, S, Peloso, GM, Gustafsson, S, Kanoni, S, Ganna, A, Chen, J, Buchkovich, ML, Mora, S, Beckmann, JS, Bragg-Gresham, JL, Chang, H-Y, Demirkan, A, Den Hertog, HM, Do, R, Donnelly, LA, Ehret, GB, Esko, T, Feitosa, MF, Ferreira, T, Fischer, K, Fontanillas, P, Fraser, RM, Freitag, DF, Gurdasani, D, Heikkilä, K, Hyppönen, E, Isaacs, A, Jackson, AU, Johansson, A, Johnson, T, Kaakinen, M, Kettunen, J, Kleber, ME, Li, X, Luan, J, Lyytikäinen, L-P, Magnusson, PKE, Mangino, M, Mihailov, E, Montasser, ME, Müller-Nurasyid, M, Nolte, IM, O'Connell, JR, Palmer, CD, Perola, M, Shungin, D, McArdle, WL, Kivimaki, M & Global Lipids Genetics Consortium 2013, 'Discovery and refinement of loci associated with lipid levels', Nature Genetics. https://doi.org/10.1038/ng.2797

TY - JOUR

T1 - Discovery and refinement of loci associated with lipid levels

AU - Willer, Cristen J

AU - Schmidt, Ellen M

AU - Sengupta, Sebanti

AU - Peloso, Gina M

AU - Gustafsson, Stefan

AU - Kanoni, Stavroula

AU - Ganna, Andrea

AU - Chen, Jin

AU - Buchkovich, Martin L

AU - Mora, Samia

AU - Beckmann, Jacques S

AU - Bragg-Gresham, Jennifer L

AU - Chang, Hsing-Yi

AU - Demirkan, Ayşe

AU - Den Hertog, Heleen M

AU - Do, Ron

AU - Donnelly, Louise A

AU - Ehret, Georg B

AU - Esko, Tõnu

AU - Feitosa, Mary F

AU - Ferreira, Teresa

AU - Fischer, Krista

AU - Fontanillas, Pierre

AU - Fraser, Ross M

AU - Freitag, Daniel F

AU - Gurdasani, Deepti

AU - Heikkilä, Kauko

AU - Hyppönen, Elina

AU - Isaacs, Aaron

AU - Jackson, Anne U

AU - Johansson, Asa

AU - Johnson, Toby

AU - Kaakinen, Marika

AU - Kettunen, Johannes

AU - Kleber, Marcus E

AU - Li, Xiaohui

AU - Luan, Jian'an

AU - Lyytikäinen, Leo-Pekka

AU - Magnusson, Patrik K E

AU - Mangino, Massimo

AU - Mihailov, Evelin

AU - Montasser, May E

AU - Müller-Nurasyid, Martina

AU - Nolte, Ilja M

AU - O'Connell, Jeffrey R

AU - Palmer, Cameron D

AU - Perola, Markus

AU - Shungin, Dmitry

AU - McArdle, Wendy L

AU - Kivimaki, Mika

AU - Global Lipids Genetics Consortium

PY - 2013/10/6

Y1 - 2013/10/6

N2 - Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P

AB - Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P

U2 - 10.1038/ng.2797

DO - 10.1038/ng.2797

M3 - Article (Academic Journal)

C2 - 24097068

SN - 1061-4036

JO - Nature Genetics

JF - Nature Genetics

ER -

Discovery and refinement of loci associated with lipid levels

Abstract

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