Disruption of mpl Activates β-Lactamase Production in Stenotrophomonas maltophilia and Pseudomonas aeruginosa Clinical Isolates

Karina Calvopina Tapia, Matthew Avison

Research output: Contribution to journalArticle (Academic Journal)peer-review

7 Citations (Scopus)
273 Downloads (Pure)

Abstract

The hyperproduction of chromosomally encoded β-lactamases is a key method of acquired resistance to ceftazidime, aztreonam, and when seen in backgrounds having reduced envelope permeability, carbapenems. Here we show that loss of Mpl, a UDP-muramic acid/peptide ligase, is a common and previously overlooked cause of chromosomally encoded β lactamase hyperproduction in clinical isolates of Stenotrophomonas maltophilia and Pseudomonas aeruginosa, important pathogens notorious for their β-lactam resistant phenotypes.
Original languageEnglish
Article numbere00638-18
Number of pages5
JournalAntimicrobial Agents and Chemotherapy
Volume62
Issue number8
Early online date29 May 2018
DOIs
Publication statusPublished - Aug 2018

Keywords

  • beta-lactamases
  • ceftazidime
  • regulation

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