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Abstract
The hyperproduction of chromosomally encoded β-lactamases is a key method of acquired resistance to ceftazidime, aztreonam, and when seen in backgrounds having reduced envelope permeability, carbapenems. Here we show that loss of Mpl, a UDP-muramic acid/peptide ligase, is a common and previously overlooked cause of chromosomally encoded β lactamase hyperproduction in clinical isolates of Stenotrophomonas maltophilia and Pseudomonas aeruginosa, important pathogens notorious for their β-lactam resistant phenotypes.
Original language | English |
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Article number | e00638-18 |
Number of pages | 5 |
Journal | Antimicrobial Agents and Chemotherapy |
Volume | 62 |
Issue number | 8 |
Early online date | 29 May 2018 |
DOIs | |
Publication status | Published - Aug 2018 |
Keywords
- beta-lactamases
- ceftazidime
- regulation
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Dive into the research topics of 'Disruption of mpl Activates β-Lactamase Production in Stenotrophomonas maltophilia and Pseudomonas aeruginosa Clinical Isolates'. Together they form a unique fingerprint.Projects
- 1 Finished
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FEC 202022 - Detecting antibiotic resistance proteins in clinical samples using proteomics.
Avison, M. B. (Principal Investigator)
13/04/16 → 12/10/17
Project: Research