Projects per year
Functional connectivity between the hippocampus and prefrontal cortex (PFC) is essential for associative recognition memory and working memory. Disruption of hippocampal–PFC synchrony occurs in schizophrenia, which is characterized by hypofunction of NMDA receptor (NMDAR)-mediated transmission. We demonstrate that activity of dopamine D2-like receptors (D2Rs) leads selectively to long-term depression (LTD) of hippocampal–PFC NMDAR-mediated synaptic transmission. We show that dopamine-dependent LTD of NMDAR-mediated transmission profoundly disrupts normal synaptic transmission between hippocampus and PFC. These results show how dopaminergic activation induces long-term hypofunction of NMDARs, which can contribute to disordered functional connectivity, a characteristic that is a hallmark of psychiatric disorders such as schizophrenia.
|Number of pages||6|
|Journal||Proceedings of the National Academy of Sciences of the United States of America|
|Early online date||15 Aug 2015|
|Publication status||Published - 1 Sep 2015|
- medial prefrontal cortex
- long - term depression
- NMDA receptor hypofunction
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- 2 Finished
31/03/14 → 29/06/17
1/03/07 → 1/03/10