A Pd-catalysed intermolecular 1,2-carboamination route to indolines from N-aryl ureas and 1,3-dienes that proceeds under mild conditions in relatively nonacidic media, is presented. The in situ generation or preformation, os palladium tosylate emerges as a key parameter in gaining the requisite reacticity for the C-H insertion/carbopalladation/nucleophilic displacement process.
|Translated title of the contribution
|Distinct Reactivity of Pd(OTs)2: The Intermolecular Pd(II)-Catalyzed 1,2-Carboamination of Dienes
|10066 - 10067
|Number of pages
|Journal of the American Chemical Society
|Published - 6 Aug 2008