Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings

Nicholas A Feasey, James Hadfield, Karen H. Keddy, Timothy J Dallman, Jan Jacobs, Xiangyu Deng, Paul Wigley, Lars Barquist Barquist, Gemma C Langridge, Theresa Feltwell, Alison E Mather, Maria Fookes, Martin Aslett, Chisomo Msefula, Samuel Kariuki, Calman A Maclennan, Robert S Onsare, François-Xavier Weill, Simon Le Hello, Michael McClellandPrerak Desai, Christopher M Parry, John Cheesbrough, Neil French, Josefina Campos, Jose A Chabalgoity, Laura Betancor, Katie L Hopkins, Satheesh Nair, Octavie Lunguya, Tristan A Cogan, Milagritos D Tapia, Samba O Sow, Sharon M Tennant, Kristin Bornstein, Myron M Levine, Dean B Everett, Robert A Kingsley, Julian Parkhill, Gordon Dougan, Melita A Gordon, Nicholas R Thomson

Research output: Contribution to journalArticle (Academic Journal)

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Abstract

An epidemiological paradox surrounds Salmonella enterica serovar Enteritidis. In high-income settings, it has been responsible for an epidemic of poultry-associated, self-limiting enterocolitis, whereas in sub-Saharan Africa it is a major cause of invasive nontyphoidal Salmonella disease, associated with high case fatality. By whole-genome sequence analysis of 675 isolates of S. Enteritidis from 45 countries, we show the existence of a global epidemic clade and two new clades of S. Enteritidis that are geographically restricted to distinct regions of Africa. The African isolates display genomic degradation, a novel prophage repertoire, and an expanded multidrug resistance plasmid. S. Enteritidis is a further example of a Salmonella serotype that displays niche plasticity, with distinct clades that enable it to become a prominent cause of gastroenteritis in association with the industrial production of eggs and of multidrug-resistant, bloodstream-invasive infection in Africa.

Original languageEnglish
Pages (from-to)1211-1217
Number of pages7
JournalNature Genetics
Volume48
Issue number10
Early online date22 Aug 2016
DOIs
Publication statusPublished - Oct 2016

Keywords

  • Bacterial infection
  • Genomics
  • Microbial genetics

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    Feasey, N. A., Hadfield, J., Keddy, K. H., Dallman, T. J., Jacobs, J., Deng, X., Wigley, P., Barquist Barquist, L., Langridge, G. C., Feltwell, T., Mather, A. E., Fookes, M., Aslett, M., Msefula, C., Kariuki, S., Maclennan, C. A., Onsare, R. S., Weill, F-X., Le Hello, S., ... Thomson, N. R. (2016). Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings. Nature Genetics, 48(10), 1211-1217. https://doi.org/10.1038/ng.3644