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Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings

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Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings. / Feasey, Nicholas A; Hadfield, James; Keddy, Karen H.; Dallman, Timothy J; Jacobs, Jan; Deng, Xiangyu; Wigley, Paul; Barquist Barquist, Lars; Langridge, Gemma C; Feltwell, Theresa; Mather, Alison E; Fookes, Maria; Aslett, Martin; Msefula, Chisomo; Kariuki, Samuel; Maclennan, Calman A; Onsare, Robert S; Weill, François-Xavier; Le Hello, Simon; McClelland, Michael; Desai, Prerak; Parry, Christopher M; Cheesbrough, John; French, Neil; Campos, Josefina; Chabalgoity, Jose A; Betancor, Laura; Hopkins, Katie L; Nair, Satheesh; Lunguya, Octavie; Cogan, Tristan A; Tapia, Milagritos D; Sow, Samba O; Tennant, Sharon M; Bornstein, Kristin; Levine, Myron M; Everett, Dean B; Kingsley, Robert A; Parkhill, Julian; Dougan, Gordon; Gordon, Melita A; Thomson, Nicholas R.

In: Nature Genetics, Vol. 48, No. 10, 10.2016, p. 1211-1217.

Research output: Contribution to journalArticle

Harvard

Feasey, NA, Hadfield, J, Keddy, KH, Dallman, TJ, Jacobs, J, Deng, X, Wigley, P, Barquist Barquist, L, Langridge, GC, Feltwell, T, Mather, AE, Fookes, M, Aslett, M, Msefula, C, Kariuki, S, Maclennan, CA, Onsare, RS, Weill, F-X, Le Hello, S, McClelland, M, Desai, P, Parry, CM, Cheesbrough, J, French, N, Campos, J, Chabalgoity, JA, Betancor, L, Hopkins, KL, Nair, S, Lunguya, O, Cogan, TA, Tapia, MD, Sow, SO, Tennant, SM, Bornstein, K, Levine, MM, Everett, DB, Kingsley, RA, Parkhill, J, Dougan, G, Gordon, MA & Thomson, NR 2016, 'Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings', Nature Genetics, vol. 48, no. 10, pp. 1211-1217. https://doi.org/10.1038/ng.3644

APA

Feasey, N. A., Hadfield, J., Keddy, K. H., Dallman, T. J., Jacobs, J., Deng, X., ... Thomson, N. R. (2016). Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings. Nature Genetics, 48(10), 1211-1217. https://doi.org/10.1038/ng.3644

Vancouver

Feasey NA, Hadfield J, Keddy KH, Dallman TJ, Jacobs J, Deng X et al. Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings. Nature Genetics. 2016 Oct;48(10):1211-1217. https://doi.org/10.1038/ng.3644

Author

Feasey, Nicholas A ; Hadfield, James ; Keddy, Karen H. ; Dallman, Timothy J ; Jacobs, Jan ; Deng, Xiangyu ; Wigley, Paul ; Barquist Barquist, Lars ; Langridge, Gemma C ; Feltwell, Theresa ; Mather, Alison E ; Fookes, Maria ; Aslett, Martin ; Msefula, Chisomo ; Kariuki, Samuel ; Maclennan, Calman A ; Onsare, Robert S ; Weill, François-Xavier ; Le Hello, Simon ; McClelland, Michael ; Desai, Prerak ; Parry, Christopher M ; Cheesbrough, John ; French, Neil ; Campos, Josefina ; Chabalgoity, Jose A ; Betancor, Laura ; Hopkins, Katie L ; Nair, Satheesh ; Lunguya, Octavie ; Cogan, Tristan A ; Tapia, Milagritos D ; Sow, Samba O ; Tennant, Sharon M ; Bornstein, Kristin ; Levine, Myron M ; Everett, Dean B ; Kingsley, Robert A ; Parkhill, Julian ; Dougan, Gordon ; Gordon, Melita A ; Thomson, Nicholas R. / Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings. In: Nature Genetics. 2016 ; Vol. 48, No. 10. pp. 1211-1217.

Bibtex

@article{22a752a68e464838a87ef824bcedfde9,
title = "Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings",
abstract = "An epidemiological paradox surrounds Salmonella enterica serovar Enteritidis. In high-income settings, it has been responsible for an epidemic of poultry-associated, self-limiting enterocolitis, whereas in sub-Saharan Africa it is a major cause of invasive nontyphoidal Salmonella disease, associated with high case fatality. By whole-genome sequence analysis of 675 isolates of S. Enteritidis from 45 countries, we show the existence of a global epidemic clade and two new clades of S. Enteritidis that are geographically restricted to distinct regions of Africa. The African isolates display genomic degradation, a novel prophage repertoire, and an expanded multidrug resistance plasmid. S. Enteritidis is a further example of a Salmonella serotype that displays niche plasticity, with distinct clades that enable it to become a prominent cause of gastroenteritis in association with the industrial production of eggs and of multidrug-resistant, bloodstream-invasive infection in Africa.",
keywords = "Bacterial infection, Genomics, Microbial genetics",
author = "Feasey, {Nicholas A} and James Hadfield and Keddy, {Karen H.} and Dallman, {Timothy J} and Jan Jacobs and Xiangyu Deng and Paul Wigley and {Barquist Barquist}, Lars and Langridge, {Gemma C} and Theresa Feltwell and Mather, {Alison E} and Maria Fookes and Martin Aslett and Chisomo Msefula and Samuel Kariuki and Maclennan, {Calman A} and Onsare, {Robert S} and Fran{\cc}ois-Xavier Weill and {Le Hello}, Simon and Michael McClelland and Prerak Desai and Parry, {Christopher M} and John Cheesbrough and Neil French and Josefina Campos and Chabalgoity, {Jose A} and Laura Betancor and Hopkins, {Katie L} and Satheesh Nair and Octavie Lunguya and Cogan, {Tristan A} and Tapia, {Milagritos D} and Sow, {Samba O} and Tennant, {Sharon M} and Kristin Bornstein and Levine, {Myron M} and Everett, {Dean B} and Kingsley, {Robert A} and Julian Parkhill and Gordon Dougan and Gordon, {Melita A} and Thomson, {Nicholas R}",
year = "2016",
month = "10",
doi = "10.1038/ng.3644",
language = "English",
volume = "48",
pages = "1211--1217",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Springer Nature",
number = "10",

}

RIS - suitable for import to EndNote

TY - JOUR

T1 - Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings

AU - Feasey, Nicholas A

AU - Hadfield, James

AU - Keddy, Karen H.

AU - Dallman, Timothy J

AU - Jacobs, Jan

AU - Deng, Xiangyu

AU - Wigley, Paul

AU - Barquist Barquist, Lars

AU - Langridge, Gemma C

AU - Feltwell, Theresa

AU - Mather, Alison E

AU - Fookes, Maria

AU - Aslett, Martin

AU - Msefula, Chisomo

AU - Kariuki, Samuel

AU - Maclennan, Calman A

AU - Onsare, Robert S

AU - Weill, François-Xavier

AU - Le Hello, Simon

AU - McClelland, Michael

AU - Desai, Prerak

AU - Parry, Christopher M

AU - Cheesbrough, John

AU - French, Neil

AU - Campos, Josefina

AU - Chabalgoity, Jose A

AU - Betancor, Laura

AU - Hopkins, Katie L

AU - Nair, Satheesh

AU - Lunguya, Octavie

AU - Cogan, Tristan A

AU - Tapia, Milagritos D

AU - Sow, Samba O

AU - Tennant, Sharon M

AU - Bornstein, Kristin

AU - Levine, Myron M

AU - Everett, Dean B

AU - Kingsley, Robert A

AU - Parkhill, Julian

AU - Dougan, Gordon

AU - Gordon, Melita A

AU - Thomson, Nicholas R

PY - 2016/10

Y1 - 2016/10

N2 - An epidemiological paradox surrounds Salmonella enterica serovar Enteritidis. In high-income settings, it has been responsible for an epidemic of poultry-associated, self-limiting enterocolitis, whereas in sub-Saharan Africa it is a major cause of invasive nontyphoidal Salmonella disease, associated with high case fatality. By whole-genome sequence analysis of 675 isolates of S. Enteritidis from 45 countries, we show the existence of a global epidemic clade and two new clades of S. Enteritidis that are geographically restricted to distinct regions of Africa. The African isolates display genomic degradation, a novel prophage repertoire, and an expanded multidrug resistance plasmid. S. Enteritidis is a further example of a Salmonella serotype that displays niche plasticity, with distinct clades that enable it to become a prominent cause of gastroenteritis in association with the industrial production of eggs and of multidrug-resistant, bloodstream-invasive infection in Africa.

AB - An epidemiological paradox surrounds Salmonella enterica serovar Enteritidis. In high-income settings, it has been responsible for an epidemic of poultry-associated, self-limiting enterocolitis, whereas in sub-Saharan Africa it is a major cause of invasive nontyphoidal Salmonella disease, associated with high case fatality. By whole-genome sequence analysis of 675 isolates of S. Enteritidis from 45 countries, we show the existence of a global epidemic clade and two new clades of S. Enteritidis that are geographically restricted to distinct regions of Africa. The African isolates display genomic degradation, a novel prophage repertoire, and an expanded multidrug resistance plasmid. S. Enteritidis is a further example of a Salmonella serotype that displays niche plasticity, with distinct clades that enable it to become a prominent cause of gastroenteritis in association with the industrial production of eggs and of multidrug-resistant, bloodstream-invasive infection in Africa.

KW - Bacterial infection

KW - Genomics

KW - Microbial genetics

U2 - 10.1038/ng.3644

DO - 10.1038/ng.3644

M3 - Article

C2 - 27548315

VL - 48

SP - 1211

EP - 1217

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 10

ER -