Distinguishing Ewing sarcoma and osteomyelitis using FTIR spectroscopy

Radosław Chaber*, Christopher J. Arthur, Joanna Depciuch, Kornelia Łach, Anna Raciborska, Elżbieta Michalak, Józef Cebulski

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

9 Citations (Scopus)
174 Downloads (Pure)

Abstract

The differential diagnosis of Ewing sarcoma and osteomyelitis can be challenging and can lead to delays in treatment with possibly devastating results. In this retrospective, small-cohort study we demonstrate, that the Fourier Transformed Infrared (FTIR) spectra of osteomyelitis bone tissue can be differentiated from Ewing sarcoma and normal bone tissue sampled outside tumour area. Significant differences in osteomyelitis samples can be seen in lipid and protein composition. Supervised learning using a quadratic discriminant analysis classifier was able to differentiate the osteomyelitis samples with high accuracy. FTIR spectroscopy, alongside routine radiological and histopathological methods, may offer an additional tool for the differential diagnosis of osteomyelitis and ES.

Original languageEnglish
Article number15081
Number of pages8
JournalScientific Reports
Volume8
DOIs
Publication statusPublished - 18 Oct 2018

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